Nitric Oxide: Biology And Pathobiology

Hardcover | April 1, 2017

byLouis J. IgnarroEditorBruce Freeman

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Nitric Oxide: Biology and Pathobiology, Third Edition provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Includes perspectives from Jack Lancaster on the discovery of EDRF and nitric oxide Provides detailed coverage of the new gaseous signaling agents Features expanded coverage on the principles of biology, including nitric oxide synthases, nitrite and nitrate biology and pathobiology, and signaling mechanisms Incorporates expanded pathobiology coverage, including nitric oxide and cardiovascular function, obesity, diabetes, and erectile function/dysfunction

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Nitric Oxide: Biology and Pathobiology, Third Edition provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aer...

Louis J Ignarro is the Recipient of the 1998 Nobel Prize in Physiology or Medicine for demonstrating the signaling properties of nitric oxide. He is presently a Professor Emeritus at the Centre for Health Sciences, UCLA. His various other accolades include the 1998 Basic Research Price of the American Heart Association membership of th...

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Format:HardcoverDimensions:864 pages, 9.41 × 7.24 × 0.98 inPublished:April 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128042737

ISBN - 13:9780128042731

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Table of Contents

Section I. Chemical Biology 1. Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes 2. Nitric oxide redox biochemistry in lipid environments 3. Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration 4. Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

Section II. Principles of Biology A. Nitric Oxide Synthases5. Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal 6. Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases 7. Regulation of the expression of inducible nitric oxide synthase 8. Molecular Regulation of Inducible Nitric Oxide SynthaseB. Guanylate Cyclase and Cyclic GMP9. Soluble Guanylate Cyclase: Allosteric Activation and Redox RegulationC. Nitric Oxide Signaling10. Untargeted Discovery of NO-modified Proteins 11. Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids 12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric OxideD. Regulation of Nitric Oxide Production14. Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence E. Nitric Oxide and Remodeling 15. The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational StudiesF. Nitrite and Nitrate16. NO formation from inorganic nitrate and nitrite 17. Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential 18. Nitrite Therapy for Ischemic Syndromes 19. Nitrite and heme globins: Reaction mechanisms and physiological targets

Section III. Principles of Pathobiology A. Nitric Oxide and Cardiovascular Function20. Nitric Oxide in Vascular Damage and Regeneration 21. Free radicals as atherosclerotic risk-The relation of NO- 22. The role of oxidative stress in endothelial dysfunction and vascular inflammationB. Pathophysiological Mechanisms of Nitric Oxide23. Nitric oxide, oxidative stress, immune response and critical care 24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury 25. Nitric oxide in airway inflammation 26. Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance