NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection by Martin Lorenz SteinNMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection by Martin Lorenz Stein

NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus…

byMartin Lorenz Stein

Hardcover | July 17, 2014

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Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.
Title:NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus…Format:HardcoverDimensions:71 pagesPublished:July 17, 2014Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319079131

ISBN - 13:9783319079134

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Table of Contents

Introduction.- Objective.- Materials and Methods.- Results.- Discussion.