Non-dopamine Lesions in Parkinsons Disease

Hardcover | November 29, 2010

EditorGlenda M. Halliday, Roger A. Barker, Dominic B. Rowe

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Parkinson's disease becomes apparent only after substantial loss (60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has onlybeen recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's diseaseby assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classicmotor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are allreviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize thedisease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.

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Parkinson's disease becomes apparent only after substantial loss (60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has onlybeen recognized more recently. Degeneration in...

Glenda M. Halliday, PhD, is a neuroscientist currently working on the pathogenesis of neurodegenerative diseases. Her research has highlighted broader pathological involvement in Parkinson's disease and especially in dementia with Lewy bodies, with recent work suggesting that humoral immunity is involved. Roger A. Barker, PhD did his ...

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Format:HardcoverDimensions:328 pages, 9.25 × 6.12 × 0.98 inPublished:November 29, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195371089

ISBN - 13:9780195371086

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Table of Contents

Contributors1. Stanley Fahn and Glenda M. Halliday: Lesions Associated with the Classic Triad of Parkinsonian Motor Features2. Anna Rita Bentivoglio, Davide Quaranta, and Aileen K. Ho: Lesions Associated with Motor Speech3. Andrew W. Michell, Roger A. Barker, and Glenda M. Halliday: Lesions Associated with Eye Movements4. Richard L. Doty, Christopher Hawkes, and Henk W. Berendse: Olfactory Dysfunction in Parkinson's Disease and Related Disorders5. Lesions Associated with Autonomic DysfunctionMaria G. Cersosimo and Eduardo E. Bennarroch: A: Swallowing Disorders and DroolingAdolfo Minguez-Castellanos and Dominic B. Rowe: B: Gastrointestinal DisordersSpiridon Papapetropoulos and Kathryn K. Post: C: Orthostatic Hypotension6. Andreas Hartmann and Glenda M. Halliday: Lesions Associated with Pain and Sensory Abnormalities7. Marcus M. Unger, Wolfgang H. Oertel, Thomas C. Thannickal, Yuan-Yang Lai, and Jerome M. Siegel: Lesions Associated with Sleep Disturbances8. Uwe Ehrt, Kenn F. Pedersen, and Dag Aarsland: Lesions Associated with Depression and Apathy9. Andrew H. Evans: Lesions Associated with Dyskinesias and the Dopamine Dysregulation Syndrome10. David R. Williams and Werner Poewe: Lesions Associated with Visual Hallucinations and Psychoses11. Jonathan Evans, Tamas Revesz, and Roger A. Barker: Lesions Associated with Cognitive Impairment and Dementia12. Dominic B. Rowe: Systemic Manifestations of Parkinson's DiseaseIndex