Non-Mendelian Genetics in Humans by Harry OstrerNon-Mendelian Genetics in Humans by Harry Ostrer

Non-Mendelian Genetics in Humans

byHarry Ostrer

Hardcover | January 1, 1998

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When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance,variable expressivity, and preferential parental transmission. In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectualheirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viralinfection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics. In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypescannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in their occurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotypewill improve in the future as all of the human genes are identified, such predictions will always remain imprecise.
Harry Ostrer, M.D., is Associate Professor of Pediatrics and Pathology and Director of the Human Genetics Program at New York University Medical Center. His current research is concentrated in the areas of genetic control of male sexual development, the genetic basis of cancer susceptibility, human population genetics, and assuring fai...
Title:Non-Mendelian Genetics in HumansFormat:HardcoverDimensions:216 pages, 9.02 × 6.3 × 1.18 inPublished:January 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195068777

ISBN - 13:9780195068771

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Table of Contents

1. Mendelian Inheritance in Humans2. The Molecular Basis of Mendelian Disease3. Deviations from the Mendelian Paradigm4. Chromosomal Transmission5. Sex Chromosome Transmission6. Mitochondrial Inheritance7. Genomic Imprinting8. Accelerated Rates of Mutation9. Viral Infection10. Human Variation: Determinism or Chance