Novel Pharmacological Inhibitors for Bacterial Protein Toxins by Holger BarthNovel Pharmacological Inhibitors for Bacterial Protein Toxins by Holger Barth

Novel Pharmacological Inhibitors for Bacterial Protein Toxins

Guest editorHolger Barth

Paperback | June 8, 2017

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Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.

Title:Novel Pharmacological Inhibitors for Bacterial Protein ToxinsFormat:PaperbackProduct dimensions:124 pages, 9.61 × 6.69 × 0.34 inShipping dimensions:9.61 × 6.69 × 0.34 inPublished:June 8, 2017Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038424307

ISBN - 13:9783038424307


Table of Contents

1)  Editorial-Holger Barth
2) Kavaliauskiene et al. Protection against Shiga toxin
3) Lam et al.  Probiotic microorganisms inhibit epithelial cell internalization of botulinum neurotoxin serotype A
4) Li et al. Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets
5) Schelle et al. Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
6) Schnell et al. Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication
7) Yamini et al. Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study
8) Kronhardt et al. Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells