Novel (trans)dermal Drug Delivery Strategies: Micro- And Nano-scale Assessments by Garvie-cook HazelNovel (trans)dermal Drug Delivery Strategies: Micro- And Nano-scale Assessments by Garvie-cook Hazel

Novel (trans)dermal Drug Delivery Strategies: Micro- And Nano-scale Assessments

byGarvie-cook Hazel

Paperback | March 30, 2018

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This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

Hazel Garvie-Cook received her M.Phys degree in Physics from Durham University in 2011 and a PhD in (trans)dermal drug delivery strategies from the University of Bath in 2014. Since finishing her PhD, she has stayed on at the University of Bath as a Research Associate in the Department of Pharmacy & Pharmacology. Her research interests...
Title:Novel (trans)dermal Drug Delivery Strategies: Micro- And Nano-scale AssessmentsFormat:PaperbackDimensions:114 pagesPublished:March 30, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319804537

ISBN - 13:9783319804538


Table of Contents

Introduction.- Background.- Methodology.- TEC Plasticization of Topical Polymeric  Films.- Lipid Incorporation into Topical Polymeric Films.- Laser Microporation of Skin.- Conclusion.