Nuclear Organization, Chromatin Structure and Gene Expression: Nuclear Orgn Chromatin Structu

Hardcover | October 1, 1997

EditorRoel Van Driel, Arie P. Otte

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This is one of the first books that focuses on emerging concepts about the role of the structure of chromatin, the organization of the genome, and the structure of the interphase nucleus in the control of gene expression in eukaryotes. The first section analyses the relationship between thedynamic chromatin structure at the nucleosome level and gene expression. Section two looks into higher order chromatin structure in relation to transcription. In section three the molecular basis of epigenetic phenomena, like X-chromosome inactivation is discussed, starting from our understanding ofchromatin structure. Together, these topics form the molecular basis for our understanding of cell differentiation, knowledge that is essential for the design of transgenic animals and plants and for gene therapy in humans. The book is of direct interest to students that are new in the field and toinvestigators in the area of biomolecular sciences, like developmental biology, biochemistry, cell biology, microbiology and genetics. Also, those working in applied fields of research, i.e biotechnology and biomedicine, will strongly benefit from this book. It will help them to understandfundamental problems in transgenics and gene therapy. Importantly, a variety of human disorders may turn out to be caused by genetic or somatic errors related to this level of gene control.

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This is one of the first books that focuses on emerging concepts about the role of the structure of chromatin, the organization of the genome, and the structure of the interphase nucleus in the control of gene expression in eukaryotes. The first section analyses the relationship between thedynamic chromatin structure at the nucleosome ...

Dr Roel Van Driel, E.C Slater Institut, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands. Tel: +31 20 525 5150; Fax:+31 20 525 5124: Email: van.driel@chem.uva.nl Dr Arie P Otte, E. C Slater Institut, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands. Tel: +31 2...

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Format:HardcoverDimensions:308 pages, 9.21 × 6.14 × 0.83 inPublished:October 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198549237

ISBN - 13:9780198549239

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Table of Contents

Introduction, general perspective, scope of book, key questionsPart 1: Nucleosome Dynamics and Transcription1.2. Role of a positioned nucleosome in constitutive repression and hormone induction of the MMTV promoter1.3. Histone modification and transcriptional competence1.4. Mechanisms for alleviating chromatin-mediated repression of transcriptionPart 2: Higher Order Structure of the Genome and the Nucleus2.1. Chromatin domains and boundary elements2.2. Nuclear matrix associated regions2.3. The chicken lysozyme chromatin domain2.4. Locus control regions2.5. Interphase chromosome positions and structure during silencing, transcription and replication2.6. Genes and transcripts in the interphase nucleusPart 3: Biological Structure and Epigenetic Control of Gene Expression3.1. DNA methylation and genomic imprinting3.2. X chromosome inactivation and heritable chromatin structure3.3. Drosophila heterochromatin: retreats for repeats3.4. Mechanisms of heritable gene silencing during development of Drosophila3.5. Heterochromatin and regulation of gene expression in Saccharomyces cerevisiae3.6. Homology-dependent gene silencing in transgenic plants and related phenomena in other eukaryotes

Editorial Reviews

"ÝT¨his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in generegulation . . ., and epigenetic regulation of transcription . . . ÝT¨he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the precedingarticles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many freshperspectives not found in previously published books in this field."--The Quarterly Review of Biology