Nuclear Receptors: A Practical Approach

Paperback | July 22, 1999

EditorDidier Picard

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The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone andcharacterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section coversreceptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can beregulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.

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From the Publisher

The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone andcharacterize new receptors. Chapter 3 shows how to iden...

Didier Picard is at University of Geneva.

other books by Didier Picard

Format:PaperbackPublished:July 22, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637423

ISBN - 13:9780199637423

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Table of Contents

PrefaceTable of ContentsList of Contributors1. Evolutionary biology of the nuclear receptor superfamily2. Initial characterization of new orphan receptors3. Adopting orphans: finding ligands4. Kinetic analysis of nuclear receptor interactions5. Functional characterization of coactivators using mammalian cell microinjection6. Analysis of steroid/nuclear receptor phosphorylation7. Ligand- and cofactor-regulated transcription with chromatin templates8. Hormone resistance syndromes9. In Vitro assembly of steroid receptor - Hsp90 complexes10. Yeast as a system for the study of nuclear receptor function11. Regulation of heterologus proteins by fusion to a hormone binding domainList of non-standard AbbreviationsList of suppliersAppendices

Editorial Reviews

"Dr Picard has done an excellent job in bringing together a range of exciting techniques that are currently being used to futher our understanding of this fascinating and ever growing family of 'Nuclear Recptors" Cell Biology International