Nuclear Receptors: Current Concepts and Future Challenges by Chris M. BunceNuclear Receptors: Current Concepts and Future Challenges by Chris M. Bunce

Nuclear Receptors: Current Concepts and Future Challenges

byChris M. BunceEditorMoray J. Campbell

Paperback | May 5, 2012

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In 1980 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient's condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification vitamin D3 and its sunlight driven production in skin paved the way to the elimination of rickets as a major medical problem. Twenty years or so later Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between in 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.
Title:Nuclear Receptors: Current Concepts and Future ChallengesFormat:PaperbackDimensions:458 pagesPublished:May 5, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9400731736

ISBN - 13:9789400731738

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Table of Contents

Preface, Sebastiano Battaglia, Pedro VelicaNuclear Receptors an introductory overview, Chris M. Bunce, Moray J. CampbellWhat does evolution teach us about Nuclear Receptors?, Gabriel Markov, François Bonneton, Vincent LaudetFunctions of Nuclear Receptors in Insect Development, David MartínThe Glucocorticoid Receptor, Robert H. Oakley, John A. CidlowskiEstrogen Receptors: Their actions and functional roles in health and disease, Stefan Nilsson, Jan-Åke GustafssonAndrogen Receptor, James T. Dalton, Wenqing GaoThyroid hormone receptors, Björn Vennström, Hong Liu, Douglas ForrestThe Vitamin D receptor, Orla Maguire, Moray J. CampbellRetinoic acid Receptors, Audrey Cras, Fabien Guidez, Christine ChomiennePPARs: important regulators in metabolism and inflammation, Linda M. Sanderson, Sander KerstenXenobiotic Receptors CAR and PXR, Curtis Klaassen, Hong LuFXR, Yandong Wang, Weidong Chen, Xiaosong Chen, Wendong HuangPhysiological Functions of TR2 and TR4 Orphan Nuclear Receptor, Liu Su, Shaozhen Xie, YiFen Lee, Chawnshang ChangNuclear Receptors and ATP Dependent Chromatin Remodeling: A Complex Story, Craig J. Burd, Trevor K. ArcherNon-Genomic Action of Sex Steroid Hormones, Antimo Migliaccio, Gabriella Castoria, Ferdinando AuricchioLigand regulation and nuclear receptor action, Martin HewisonNew insights to nuclear receptor gene regulation from analysis of their response elements in target genes, Carsten CarlbergSystems biology: towards realistic and useful models of molecular networks, F.J. Bruggeman, A. Kolodkin, K. Rybakova, M. Moné, H.V. WesterhoffIndex