Nucleic Acid Structure and Recognition

Paperback | July 1, 2002

byStephen Neidle

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This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigationfor nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies areanalysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent andnon-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.

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This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigationfor nucleic acids: X-ray crystallography, NMR...

Stephen Neidle, The Institute of Cancer Research (University of London).

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Format:PaperbackDimensions:188 pages, 9.45 × 6.61 × 0.48 inPublished:July 1, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019850635X

ISBN - 13:9780198506355

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Table of Contents

1. Methods for studying nucleic acid structure2. The building blocks of nucleic acids3. Helical DNA and RNA structures4. Non-classical DNA structures5. Principles of small molecule DNA Recognition6. Complex RNA structures7. DNA-protein interactions

Editorial Reviews

"Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances. ... nothing can replace the perspective that someone of Steve's experience brings to this subject. ... let me congratulate Steve on making this
subject so accessible to such a potentially wide audience."--Crystallography News