Oncogenes and Tumour Suppressors: Frontiers in Molecular Biology

Paperback | July 1, 1997

EditorGordon Peters, Karen Vousden

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Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present andcritically assess our current knowledge. The book covers two major areas of interest: oncogenes and signal transduction, and tumour supressors and cell cycle control. Topics covered include the mechanisms of oncogene perturbation; growth factors and their receptors in cell transformation; oncogeniccytoplasmic protein tyrosine kinases; the RAS/RAP/ERK signal transduction pathway; oncogenic transcription factors; mammalian cell cycle control; the retinoblastoma gene product and its relatives; the tumour suppressor gene p53; tumour suppressors and the inheritance of cancer; the clinicalrelevance of oncogenes. Oncogenes and Tumour Suppressors is a major review work that provides an unparalleled summary of our current understanding of this field as viewed by some of its leading researchers. It is of interest to all those involved in research on the cell cycle, signal transduction,and cancer biology. The book is also an excellent reference source with over 1800 selected citations to the primary literature.

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Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present andcritically assess our current knowledge. The book c...

Gordon Peters, Principal Investigator, ABL Basic Research Program, NCI, Maryland. Karen Vousden, Principal Scientist, Imperial Cancer Research Fund, London.

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Format:PaperbackDimensions:352 pages, 9.69 × 7.44 × 0.01 inPublished:July 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199635943

ISBN - 13:9780199635948

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Table of Contents

Part I: Oncogenes and Signal Transduction1. Mechanisms of oncogene preturbation2. Growth factors3. Growth factor receptors in cell transformation4. Oncogenic cytoplasmic protein tyrosine kinases5. The RAS/RAF/ERK signal transduction pathway6. Oncogenic transcription factors: FOS, JUN, MYC, MYB, and ETSPart II: Tumour suppressors and cell cycle control7. Mammalian cell cycle control8. The retinoblastoma gene product and its relatives9. The tumour suppressor gene p5310. Tumour suppressor genes and inheritance of cancer11. Clinical relevance of oncogenes

Editorial Reviews

" ... an excellent historical overview of the field ... a welcome addition to hospital or university libraries." Clinical and Investigative Medicine (Oct 1998)