Optimization of Aerosol Drug Delivery by Leon GradonOptimization of Aerosol Drug Delivery by Leon Gradon

Optimization of Aerosol Drug Delivery

EditorLeon Gradon, J.C. Marijnissen

Paperback | December 30, 2010

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Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
Title:Optimization of Aerosol Drug DeliveryFormat:PaperbackDimensions:324 pagesPublished:December 30, 2010Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048164362

ISBN - 13:9789048164363

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Table of Contents

Introduction A history of the development of therapy by jet nebulisation; Ola NerbrinkMolecular modelling in drug design; Bogdan Lesyng and Witold Rudnicki Particle elaboration using supercritical media for drug delivery into the human lungs; Jerzy Baldyga and Marek Henczka Electrospray as means to produce monodisperse drug particles; Kees Geerse and Jan MarijnissenOptimization of dry powder aerosols for systemic drug delivery; Rita VanbeverRecent advances in drug delivery via pressurised metered-dose inhalers; John PritchardResuspension of powders and deposition of aerosol particles in the upper human airways; Leon Gradon, Tomasz Sosnowski and Arkadiusz MoskalTransport and deposition of hydrophilic drug particles in the lungs; Joachirn Heyder, Josef Gebhart, Christa Roth and George Ferron Ventilation modelling and drug deposition in very young asthmatic children; Frans de Jongh and Rupino Griffioen Modeling aerosol drug delivery; Yung Sung ChengApplication of electro hydro dynamic atomisation in the production of engineered drug particles; Tomasz Ciach, Lidia Diaz, Esther van den IJssel and Jan MarijnissenInteraction of deposited aerosol particles with the alveolar liquid layer; Tomasz Sosnowski, Leon Gradon, Ferry Iskandar and Kikuo Okuyama Pulmonary deposition and effects of aerosolized drugs in pulmonary patients; Eric Derom Targetting aerosols to disease areas; Pieter Zanen Treatment of asthma patients under severe conditions; Giuseppe Marraro Understanding the mechanisms of local pulmonary drug absorption and metabolism: An in vitro model of the airway epithelium; Gerrit Borchard Overview; Gerrit Borchard Keyword Index List of Authors