Optimizing the "Drug-Like" Properties of Leads in Drug Discovery by Ronald Borchardt

Optimizing the "Drug-Like" Properties of Leads in Drug Discovery

EditorRonald Borchardt, Edward Kerns, Michael Hageman

Hardcover | August 3, 2006

not yet rated|write a review

Pricing and Purchase Info

$440.95

Earn 2205 plum® points

In stock online

Ships free on orders over $25

Not available in stores

about

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Details & Specs

Title:Optimizing the "Drug-Like" Properties of Leads in Drug DiscoveryFormat:HardcoverDimensions:522 pages, 10 × 7.01 × 0 inPublished:August 3, 2006Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387340564

ISBN - 13:9780387340562

Look for similar items by category:

Customer Reviews of Optimizing the "Drug-Like" Properties of Leads in Drug Discovery

Reviews

Extra Content

Table of Contents

Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds.- Role Of Mechanistic Transport Studies in Lead Optimization.- Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions.- Case-History- Use of ADME Studies for Optimization of Drug Candidates.- Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization.- Lipid Based Systems, Drug and Lead Optimization.- Biopharmaceutics Modeling and the Role of Dose Formulation on Oral Exposure.- Application of Physiochemical Data to Support Lead Optimization by Discovery.- Computational Models Supporting Lead Optimization in Drug Discovery.- Prodrug Strategies for Improving Drug-Like Properties.- The Application of Multivariate Data Analysis to Compound Property Optimization.- Case History: Toxicology biomarker development using Toxicogenomics.- Predicting Idiosyncratic Drug Reactions.- Elementary Predictive Toxicology for Advanced Applications.- The Application of PK/PD Modeling and Simulations During Lead Optimization.- Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization.- Optimization Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development.- The Relevance of Transporters in Determining Drug Disposition.