Organic Chemistry Concepts And Applications For Medicinal Chemistry by Joseph E. RiceOrganic Chemistry Concepts And Applications For Medicinal Chemistry by Joseph E. Rice

Organic Chemistry Concepts And Applications For Medicinal Chemistry

byJoseph E. RiceEditorJoseph E. Rice

Paperback | May 6, 2014

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Organic Chemistry Concepts and Applications for Medicinal Chemistryprovides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.

  • Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding
  • Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more
  • Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
Joseph Rice received his Ph.D. in Organic Chemistry from the Polytechnic Institute of New York in 1982. He worked at the American Health Foundation in Valhalla, NY for six years doing research on chemical carcinogenesis and became Head of the Section of Metabolic Chemistry. His research involved the synthesis of potential carcinogenic ...
Title:Organic Chemistry Concepts And Applications For Medicinal ChemistryFormat:PaperbackDimensions:224 pages, 8.75 × 6.35 × 0.68 inPublished:May 6, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128007397

ISBN - 13:9780128007396

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Table of Contents

1. Bonding in Organic Compounds
a. Atomic Orbitals
b. Hybrid Orbitals
c. Resonance
d. Aromaticity
2. The Three-Dimensional Structure of Organic Compounds
a. Isomers
b. Stereoisomerism at Saturated Centers
c. Prochirality
d. Conformations
3. Functional Groups
a. Common Functional Groups
b. The Electronic Effects of Functional Groups
4. Acids and Bases
a. Bronsted-Lowry Acids and Bases
b. Ionization
c. Estimating Acid/Base Strength
d. Lewis Acids and Bases
5. Partition Coefficients
a. What is a Partition Coefficient?
b. Effect of Structure on Partition Coefficients
6. The Nomenclature of Cyclic and Polycyclic Compounds
a. Common Heterocycles
b. Fused-Ring Systems
c. Substituents and Saturation
d. Bridged-Rings
e. Spiro-Rings
f. Special Classes of Compounds
i. Steroids
ii. Prostaglandins
iii. Morphinans
7. Drug Metabolism
a. Phase I Oxidative Processes
b. Phase I Reductions
c. Phase I Hydrolysis
d. Phase II Conjugation
e. Miscellaneous Phase II Processes