organic Chemistry Of Enzyme-catalyzed Reactions, Revised Edition

Hardcover | April 6, 2002

byRichard B. SilvermanEditorRichard B. Silverman

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The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reactionMakes the connection between organic reaction mechanisms and enzyme mechanismsCompiles the latest information about molecular mechanisms of enzyme reactionsAccompanied by clearly drawn structures, schemes, and figuresIncludes an extensive bibliography on enzyme mechanisms covering the last 30 yearsExplains how enzymes can accelerate the rates of chemical reactions with high specificityProvides approaches to the design of inhibitors of enzyme-catalyzed reactionsCategorizes the cofactors that are appropriate for catalyzing different classes of reactionsShows how chemical enzyme models are used for mechanistic studiesDescribes catalytic antibody design and mechanismIncludes problem sets and solutions for each chapter Written in an informal and didactic style

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From the Publisher

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.This is a revised edition o...

Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Profe...

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Format:HardcoverDimensions:800 pages, 9 × 6 × 0.98 inPublished:April 6, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126437319

ISBN - 13:9780126437317

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Extra Content

Table of Contents

Enzymes as Catalysts
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Monooxygenation
Dioxygenation
Substitutions
Carboxylations
Decarboxylation
Isomerizations
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Rearrangements
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions

Editorial Reviews

Praise for the First Edition"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY