organic Chemistry Of Enzyme-catalyzed Reactions, Revised Edition by Richard B. Silvermanorganic Chemistry Of Enzyme-catalyzed Reactions, Revised Edition by Richard B. Silverman

organic Chemistry Of Enzyme-catalyzed Reactions, Revised Edition

byRichard B. SilvermanEditorRichard B. Silverman

Hardcover | February 28, 2002

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The Organic Chemistry of Enzyme-Catalyzed Reactionsis not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

  • Illustrates the organic mechanism associated with each enzyme-catalyzed reaction
  • Makes the connection between organic reaction mechanisms and enzyme mechanisms
  • Compiles the latest information about molecular mechanisms of enzyme reactions
  • Accompanied by clearly drawn structures, schemes, and figures
  • Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
  • Explains how enzymes can accelerate the rates of chemical reactions with high specificity
  • Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
  • Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
  • Shows how chemical enzyme models are used for mechanistic studies
  • Describes catalytic antibody design and mechanism
  • Includes problem sets and solutions for each chapter
  • Written in an informal and didactic style
Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Profe...
Title:organic Chemistry Of Enzyme-catalyzed Reactions, Revised EditionFormat:HardcoverDimensions:800 pages, 9 × 6 × 0.98 inPublished:February 28, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126437319

ISBN - 13:9780126437317

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Table of Contents

Enzymes as Catalysts
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions

Editorial Reviews

Praise for the First Edition"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY