Organic Synthesis by Michael B SmithOrganic Synthesis by Michael B Smith

Organic Synthesis

byMichael B Smith, Michael B Smith

Other | July 12, 2011

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A reactions oriented course is a staple of most graduate organic programs, and synthesis is taught either as a part of that course or as a special topic. Ideally, the incoming student is an organic major, who has a good working knowledge of basic reactions, stereochemistry and conformational principles. In fact, however, many (often most) of the students in a first year graduate level organic course have deficiencies in their undergraduate work, are not organic majors and are not synthetically inclined.

To save students much time catching up this text provides a reliable and readily available source for background material that will enable all graduate students to reach the same high level of proficiency in organic chemistry. Produced over many years with extensive feedback from students taking an organic chemistry course this book provides a reaction based approach. The first two chapters provide an introduction to functional groups; these are followed by chapters reviewing basic organic transformations (e.g. oxidation, reduction). The book then looks at carbon-carbon bond formation reactions and ways to ‘disconnect’ a bigger molecule into simpler building blocks.

Most chapters include an extensive list of questions to test the reader’s understanding. There is also a new chapter outlining full retrosynthetic analyses of complex molecules which highlights common problems made by scientists.

The book is intended for graduate and postgraduate students, scientific researchers in chemistry

    • New publisher, new edition; extensively updated and corrected
    • Over 950 new references with more than 6100 references in total
    • Over 600 new reactions and figures replaced or updated
    • Over 300 new homework problems from the current literature to provide nearly 800 problems to test reader understanding of the key principles
    Professor of Chemistry, University of Connecticut, USA
    Title:Organic SynthesisFormat:OtherDimensions:1534 pages, 1 × 1 × 1 inPublished:July 12, 2011Publisher:Elsevier ScienceLanguage:English

    The following ISBNs are associated with this title:

    ISBN - 10:0124158846

    ISBN - 13:9780124158849


    Table of Contents

    Chapter 1: Retrosynthesis, Stereochemistry, and Conformations

    Chapter 2: Acids, Bases and Functional Group Exchange Reactions

    Chapter 3: Oxidation

    Chapter 4: Reduction

    Chapter 5: Hydroboration

    Chapter 6: Stereocontrol and Ring Formation

    Chapter 7: Protecting Groups

    Chapter 8: CdDisconnect Products: Nucleophilic Species that Form Carbon-Carbon Bonds

    Chapter 9: CdDisconnect Products: Nucleophilic Species that Form Carbon-Carbon Bonds: Enolate Anions

    Chapter 10: Synthetic Strategies

    Chapter 11: Pericyclic carbon-carbon Bond Forming reactions: Multiple Bond disconnections

    Chapter 12: CaDisconnect Products: Electrophilic Carbon-Carbon Bond-Forming Reactions

    Chapter 13: Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds via Radicals and Carbenes

    Chapter 14: Student Synthesis: The First Synthetic Problem