Organic Synthesis

Other | July 12, 2011

byMichael B Smith, Michael B Smith

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A reactions oriented course is a staple of most graduate organic programs, and synthesis is taught either as a part of that course or as a special topic. Ideally, the incoming student is an organic major, who has a good working knowledge of basic reactions, stereochemistry and conformational principles. In fact, however, many (often most) of the students in a first year graduate level organic course have deficiencies in their undergraduate work, are not organic majors and are not synthetically inclined.

To save students much time catching up this text provides a reliable and readily available source for background material that will enable all graduate students to reach the same high level of proficiency in organic chemistry. Produced over many years with extensive feedback from students taking an organic chemistry course this book provides a reaction based approach. The first two chapters provide an introduction to functional groups; these are followed by chapters reviewing basic organic transformations (e.g. oxidation, reduction). The book then looks at carbon-carbon bond formation reactions and ways to ‘disconnect’ a bigger molecule into simpler building blocks.

Most chapters include an extensive list of questions to test the reader’s understanding. There is also a new chapter outlining full retrosynthetic analyses of complex molecules which highlights common problems made by scientists.

The book is intended for graduate and postgraduate students, scientific researchers in chemistry



    • New publisher, new edition; extensively updated and corrected
    • Over 950 new references with more than 6100 references in total
    • Over 600 new reactions and figures replaced or updated
    • Over 300 new homework problems from the current literature to provide nearly 800 problems to test reader understanding of the key principles
    • Free molecular modeling software to explore 60 new synthesis-oriented molecular modeling problems; designed to aid visualisation and understanding of organic synthesis

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    From the Publisher

    A reactions oriented course is a staple of most graduate organic programs, and synthesis is taught either as a part of that course or as a special topic. Ideally, the incoming student is an organic major, who has a good working knowledge of basic reactions, stereochemistry and conformational principles. In fact, however, many (often mo...

    Professor of Chemistry, University of Connecticut, USA

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    Format:OtherDimensions:1534 pages, 1 × 1 × 1 inPublished:July 12, 2011Publisher:Elsevier ScienceLanguage:English

    The following ISBNs are associated with this title:

    ISBN - 10:0124158846

    ISBN - 13:9780124158849

    Customer Reviews of Organic Synthesis

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    Extra Content

    Table of Contents

    Retrosynthesis, Stereochemistry, and Conformations

    Acids, Bases and Functional Group Exchange Reactions

    Oxidation

    Reduction

    Hydroboration

    Stereocontrol and Ring Formation

    Protecting Groups

    CdDisconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds

    CdDisconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions

    Synthetic Strategies

    Pericyclic Carbon-Carbon Bond Forming Reactions: Multiple Bond Disconnections

    CaDisconnect Products: Electrophilic Carbon-Carbon Bond Forming Reactions

    Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds Via Radicals and Carbenes

    Student Syntheses: The First Synthetic Problem

    Disconnection Index

    General Index

    Instructions and code to access Spartan software