Organic Synthetic Methods by James R. HansonOrganic Synthetic Methods by James R. Hanson

Organic Synthetic Methods

byJames R. Hanson

Paperback | December 5, 2003

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Synthesis is one of the major endeavours of the organic chemist, and the design of a successful synthesis requires a sound knowledge of functional group chemistry, stereochemistry and organic reaction mechanisms.

Organic Synthetic Methods introduces the major methods of creating carbon-carbon and carbon-nitrogen bonds, along with functional group interconversions (Oxidation, reduction, halogenation). The use of protecting groups and solid-phase methods are also discussed. The analysis of the structure of a target molecule, in terms of the structural consequences of synthetic reactions, is introduced to enable the student to identify key dissections and building blocks and hence develop a suitable synthetic method. Examples of the synthesis of labelled compounds are also provided.

James R. Hanson is Professor in the Department of Chemistry at the University of Sussex.
Title:Organic Synthetic MethodsFormat:PaperbackDimensions:176 pages, 9.7 × 7.5 × 0.38 inPublished:December 5, 2003Publisher:WileyLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:047154910X

ISBN - 13:9780471549109

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Table of Contents

1. Introduction.

1.1 Synthetic Strategies.

1.2 Steric Factors.

1.3 Criteria for Evaluating Synthetic Routes.

1.4 Some Synthetic Terms.

1.5 Learning to Apply Synthetic Methods.

2. Organometallic and Ylide Methods of carbon-Carbon Bond Formation.

2.1 Introduction.

2.2 Reactions of Organometallic Compounds.

2.3 Acetylides and Nitriles.

2.4 Ylide Reactions.

2.5 Silicon and Boron in C-C Bond Formation.

3. Carbonyl Activation and Enolate Chemistry in Carbon-Carbon Bond Formation.

3.1 Introduction.

3.2 Alkylation Reactions.

3.3 Enolate Anions in Carbonyl Addition Reactions.

3.4 The Stereochemistry of Condensation Reactions.

4. Carbocations in Synthesis.

4.1 Introduction.

4.2 Alkly Carbocations: The Friedel-Crafts Alkylation.

4.3 Carbocations Derived from Aldehydes and Ketones.

4.4 Acylium Carbocations: The Friedel-Crafts Acylation.

4.5 Acid-catalysed Rearrangement Reactions.

5. Free Radical and Pericyclic Reactions in the Formation of Carbon-Carbon Bonds.

5.1 Carbon Radical Reactions.

5.2 Radical Addition Reactions.

5.3 Carbenes.

5.4 Alkene Metathesis.

5.5 The Diels-Alder Reaction.

5.6 The Ene Reaction.

5.7 The Cope and Claisen Rearrangements.

6. Methods of Making Carbon-Nitrogen Bonds.

6.1 Introduction.

6.2 Electrophilic Methods of Making C-N Bonds.

6.3 Nucleophilic Methods of Making C-N Bonds.

6.4 Rearrangements Methods.

6.5 The Synthesis of Amino Acids.

6.6 The Synthesis of Heterocyclic Compounds.

7. Functional Group Transformations.

7.1 Oxidation.

7.2 Reduction.

7.3 Halogenation.

8. Protecting Groups.

8.1 Protection of Functional Groups.

8.2 Peptide Synthesis.

8.3 Combinatorial Synthesis.

9. Some Examples of Total Synthesis.

9.1 Introduction.

9.2 β-Eudesmol.

9.3 Griseofulvin.

9.4 Thiamine (Vitamin B1).

9.5 Prostaglandins.

Further Reading.

Answers to Problems.

Subject Index.