Origin and Evolution of Viruses

Other | June 23, 2008

byEsteban Domingo, Esteban Domingo, Colin R. Parrish...

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New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.

* NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution
* UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups
* SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

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From the Publisher

New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importan...

Format:OtherDimensions:560 pages, 1 × 1 × 1 inPublished:June 23, 2008Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080564968

ISBN - 13:9780080564968

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Table of Contents

Origins and widespread evolutionary significance of viruses; Nature and evolution of early replicons; Structure and evolution of viroids; Mutation, competition and selection as measured with small RNA molecules; Viral quasispecies, fitness variations and error;Phylogenetic analysis of viral sequences: principles and applications; Evolution of functional protein motifs in RNA viruses; Copying fidelity of viral and cellular polymerases; RNA interference and its evolutionary implications; Phage models of virus adaptation and evolution; Genomic analysis and evolution of large bacteriophages; Plant virus evolution: past, present and future; Mutant clouds and bottleneck events in plant virus evolution; Retrovirus evolution and pathogenesis; HIV population dynamics and drug treatments; The impact of rapid evolution of hepatitis viruses; Evolution of animal and human influenza viruses; Evolution and emergence of arboviruses; Parvovirus variation and evolution: impact on disease emergence; Genome diversity and evolution of human papillomaviruses; Poxvirus diversity and evolution; The molecular evolutionary history of the herpesviruses; Cellular functions involved in virual hypermutagenesis.