Osteogenesis Imperfecta: A Translational Approach To Brittle Bone Disease

Hardcover | September 11, 2013

byPeter H. ByersEditorFrancis H. Glorieux, Paul Sponseller

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Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI. Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta OI as will the importance of nutrition in managing the OI child and the OI adult Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI

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From the Publisher

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the ...

Dr. Jay R. Shapiro is a graduate of Franklin and Marshall College and the Boston University School of Medicine. He serves as Professor in the Department of Physical Medicine and Rehabilitation and Director of the Bone and Osteogenesis Imperfecta Department at the Kennedy Krieger Institute. He served as Director of the General Clinical ...

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Format:HardcoverDimensions:578 pages, 10.88 × 8.5 × 0.98 inPublished:September 11, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123971659

ISBN - 13:9780123971654

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Extra Content

Table of Contents

Foreword

Acknowledgments

List of Contributors

Section 1: INTRODUCTION

Section 2: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY

Section 3: CLINICAL AND MOLECULAR GENETICS OF OSTEOGENESIS IMPERFECTA

Section 4:COL1A1ANDCOL1A2MUTATIONS

Section 5: ANIMAL MODELS OF OSTEOGENESIS IMPERFECTA

Section 6: BRITTLE BONE OVERLAP PHENOTYPES: TGF-BETA MUTATIONS AND BONE

Section 7: CLINICAL ASPECTS OF OSTEOGENESIS IMPERFECTA

Section 8: ORGAN INVOLVEMENT IN OSTEOGENESIS IMPERFECTA

Chapter 9: ORTHOPEDICS

Section 10: PHYSICAL MEDICINE AND REHABILITATION

Section 11: PHARMACOLOGIC TREATMENT OF OSTEOGENESIS IMPERFECTA

Section 12: GENETIC APPROACH TO TREATMENT OF OSTEOGENESIS IMPERFECTA

Index

Editorial Reviews

"Shapiro., Byers, Glorieux, and Sponseller compile 58 chapters by an international group of orthopedists, geneticists, bone specialists, and other physicians and researchers, who describe osteogenesis imperfecta. They address the basic science and clinical practice, as well as future research and its relevance to treatment and care, for basic scientists and clinicians."--Reference & Research Book News, December 2013 "A monumental nearly 600 page textbook about OI has recently been published. This comprehensive reference is a collection of chapters by an international group of physicians and researchers.Their goal was to bring together in one volume the latest information about the biochemistry, genetics, research questions and treatments available to manage OI in children and adults. A special feature is an advanced discussion of surgical techniques applicable to OI."--OI Foundation E-News, September 2013