Osteoimmunology: Interactions of the Immune and Skeletal Systems

Other | September 24, 2010

byJoseph Lorenzo, Joseph Lorenzo, Yongwon Choi...

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Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated.
The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.

  • Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work

  • Experts in bone biology and immunology (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.

  • Clear presentations by bone biologists of the cellular and molecular mechanisms underlying bone cell development leading to bone and immunological diseases such as Lupus

  • Clear presentations by immunologists of how immune cells develop and how the immune system plays a role in bone diseases like osteoporosis and arthritis

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Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disea...

Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and int...

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Format:OtherDimensions:470 pages, 1 × 1 × 1 inPublished:September 24, 2010Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123756715

ISBN - 13:9780123756718

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Table of Contents

Chapter 1

Overview: The developing Field of Osteoimmunology

Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo

Chapter 2

The Origins of Bone Cells: Osteoclasts

G. David Roodman, Deborah L. Galson

Chapter 3

Adaptive Immune Response

David G. Hesslein, Hector L. Aguila, Mark C. Horowitz

Chapter 4

The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche

Henry Kronenberg, Joy Wu

Chapter 5

The Signaling Pathways Regulating Osteoblast Differentiation

Jane Lian, Gary Stein

Chapter 6

The Signaling Pathways Regulating Osteoclast Differentiation

Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi

Chapter 7

The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells

Joseph Lorenzo

Chapter 8

Interactions of Osteoblasts and Osteoclasts

T. John Martin, Natalie A. Sims, Julian M. W. Quinn

Chapter 9

The Role of the Immune System in the Development of Osteoporosis

Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder

Chapter 10

The Role of the Immune System in the Bone Loss of Inflammatory Arthritis

Georg Schett, Steven Goldring

Chapter 11

The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease

Francisco Sylvester, Anthony T. Vella

Chapter 12

The Role of the Immune System in Fracture Healing

Louis Gerstenfeld, Thomas Einhorn, Brandon Steen

Chapter 13

The Role of the Immune System in the Development of Chronic Infections of Bone

Brendan Boyce, Edward Schwarz, Lianping Xing

Chapter 14

The Role of the Immune System in Hematologic Malignancies, which Affect Bone

Gregory Mundy, Claire M. Edwards, Jessica Fowler

Chapter 15

The Role of the Immune System in Dental Disease

Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet