Osteoporosis

Other | November 8, 2007

byDavid Feldman, Robert Marcus, Robert Marcus...

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Now in its third edition,Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

NEW TO THIS EDITION:
*Recognizes the critical importance of the Wnt signaling pathway for bone health
*Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
*Examines essential updates on estrogen prevention and treatment and the recent results from the WHI
*Discusses the controversial topics of screening and clinical trial design for drug registration
*Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
* Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

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From the Publisher

Now in its third edition,Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 mill...

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Directo...

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Format:OtherDimensions:2016 pages, 1 × 1 × 1 inPublished:November 8, 2007Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080553478

ISBN - 13:9780080553474

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Table of Contents

Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
Understanding of Osteoporosis
Basic Science/Bone Biology
Osteoblast Biology
Osteoclast Biology
Osteocytes
The Regulatory Role of Matrix Proteins in Mineralization of Bone
Development of the Skeleton
Mouse Genetics as a Tool to Study Bone Development and Physiology
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens and Skeletal Biology: Basic Mechanisms
Phosphatonins
Wnt Signaling in Bone
Cytokines and Bone Remodeling
Skeletal Growth Factors
Intercellular Communication During Bone Remodeling
Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth, Aging and Disease
Inhibition of Osteoporosis by Biophysical Intervention
Biomechanics of Age-Related Fractures
Bone Quality
Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis
Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Bone Acquisition in Adolescence
Genetic Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prevention of Osteoporosis and Associated Fractures
Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis
Non-Skeletal Risk Factors for Osteoporosis and Fractures
Falls as Risk Factors for Fracture
Assessment of Fracture Risk
Outcomes of Osteoporotic Fractures
Pathophysiology
Local and Systemic Factors in the Pathogenesis of Osteoporosis
Animal Models for Osteoporosis
Estrogen, Bone Homeostasis and Osteoporosis
Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
Osteoporosis in Childhood and Adolescence
Glucocorticoid-Induced Osteoporosis
Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach
Mechanisms of Immobilization-induced Bone Loss
Leptin-Dependent Regulation of Bone Mass
Thyroid Hormone and the Skeleton
Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease
The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis
Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
Osteoporosis Associated with Illnesses and Medications
Transplantation Osteoporosis
Osteoporosis Associated with Cancer Therapy
Osteoporosis Associated with Pregnancy
Osteoporosis Associated with Rheumatologic Disease
Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks
Localized Osteoporosis
Evaluation and Management
Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
Who Should be Screened: Who Should be Treated?
Radiology of Osteoporosis
Clinical Use of Bone Densitometry
Biochemical Markers of Bone Turnover in Osteoporosis
The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis
An Orthopedic Perspective of Osteoporosis
Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs
Pharmacology and Therapeutics
Design Considerations for Clinical Investigations of Osteoporosis
Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials
Evidence-Based Osteoporosis Care
The Role of Calcium in the Treatment of Osteoporosis
Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis
Estrogen Therapy: Prevention and Treatment of Osteoporosis
Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens
Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis
Calcitonin in Osteoporosis
Strontium Therapy for Osteoporosis
Androgens
Treatment with PTH Peptides
Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
New approaches to Osteoporosis Therapeutics