Outline of Crystallography for Biologists

Paperback | March 1, 2002

byDavid Blow

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Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those withminimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an extensive reference section and suggestions for further reading for those who wish to delvedeeper.The first part 'Fundamentals' presents the underlying ideas which allow x-ray structure analysis to be carried out and provides an appropriate background to courses in structural determination.The second part 'Practice' gives more information about the procedures employed in the course of crystal structure determination. The emphasis is on the quality measures of X-ray diffraction analysis to give the reader a critical insight into the quality and accuracy of a structure determination andto enable the reader to appreciate which parts of a structure determination may have caused special difficulty.There is no pretence of completeness and many matters discussed in standard crystallography texts are deliberately omitted. However, issues not brought out in the standard texts are discussed, making it a useful resource for non-practising crystallographers as well.

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Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those withminimal mathematical knowledge. Some mathematic...

David Blow is a Senior Research Fellow, Imperial College of Science, Technology, and Medicine, London.

other books by David Blow

Format:PaperbackDimensions:248 pages, 9.45 × 6.61 × 0.53 inPublished:March 1, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198510519

ISBN - 13:9780198510512

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Table of Contents

Part 1: Fundamentals1. Images and X-rays2. Symmetry3. Waves4. Diffraction5. Diffraction by crystalsPart 2: Practice6. Intensity measurements7. Isomorphous replacement8. Anomalous scattering9. Molecular replacement10. Density-modification procedures - improving a calculated map before interpretation11. Electron density maps12. Structural refinement13. Accuracy of the final model

Editorial Reviews

"David Blow is one of the grand masters of protein crystallography and has made many major contributions to the field ... I can warmly recommend it to novices and experts alike."--Crystallography News "[A] welcome addition to the small league of books that try to make physical techniques less daunting ... an extremely useful volume [with] ... high educational value ... the author is to be applauded."The Quarterly Review of Biology