Oxford Handbook of Nucleic Acid Structure

Hardcover | February 1, 1999

EditorStephen Neidle

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The Oxford Handbook of Nucleic Acid Structure is a comprehensive reference text on all aspects of nucleic acid sturcture. Particular emphasis is placed on the results from X-ray crystallography and NMR studies, with both methods being given equal weight. The nineteen chapters describe indetail the variety of DNA and RNA structural types discovered to date with all the major 'native' structures being represented. The text progresses systematically through the polymorphs of double helical DNA through to the higher-order organizations of triplexes, quadruplexes, and junctions, then toRNA structures in their various degrees of complexity. Each chapter has been written by authorities in the field who have worked together to provide this comprehensive text on nucleic acid structure. The whole project has been brought together and edited by Professor Stephen Neidle who is Directorof the CRC Biomolecular Structure Unit at the Institute of Cancer Research.

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The Oxford Handbook of Nucleic Acid Structure is a comprehensive reference text on all aspects of nucleic acid sturcture. Particular emphasis is placed on the results from X-ray crystallography and NMR studies, with both methods being given equal weight. The nineteen chapters describe indetail the variety of DNA and RNA structural typ...

Stephen Neidle is at University of London.

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Format:HardcoverPublished:February 1, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198500386

ISBN - 13:9780198500384

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Table of Contents

1. [data missing]2. Polynucleotide secondary structures: an historical perspective3. Base and base pair morphologies, helical parameters, and definitions4. The nucleic acid database: a research and teaching tool5. Simulation of nucleic acid structure6. A-DNA duplexes in the crystal7. Helix structure and molecular recognition by B-DNA8. The single-crystal structures of Z-DNA9. Standard DNA duplexes and RNA-DNA hybrids in solution10. Nucleic acid hydration11. Single crystal X-ray diffraction studies on the non Watson-Crick base associations of mismatches, modified bases, and non-duplex oligonucleotide structures12. DNA mismatches in solution13. Structures on nucleic acid triplexes14. [data missing]15. DNA bending by adenine-thymine tracts16. Structures and interactions of helical junctions in nucleic acids17. DNA higher-order structures18. Crystallographic structures of RNA oligoribonucleotides and ribozymes19. RNA structure in solution20. Transfer RNA