Palladium In Heterocyclic Chemistry: A Guide For The Synthetic Chemist

Paperback | December 19, 2006

byJie Jack LiEditorGordon W. Gribble

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Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially. These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 1. Palladium chemistry of heterocycles has its "idiosyncrasies" stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of they are highlighted in boxes throughout the text have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry will keep readers abreast of such a fast-growing field. We also hope this book will spur more interest and inspire ideas in such an extremely useful area. This book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle. The large body of data regarding palladium-mediated polymerization of heterocycles in material chemistry is not focused here; neither is coordination chemistry involving palladium and heterocycles. Many heterocycle-containing natural products highlighted throughout the text have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry keeps readers abreast of this fast-growing field. It is also hoped that this book will stimulate more interest and inspire new ideas in this exciting field. - Contains the most up-to-date developments in this fast-moving field- Includes 3 new chapters- Contains material from selected well-respected authors on heterocyclic chemistry

From the Publisher

Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of ch...

Gordon Gribble is the Dartmouth Professor of Chemistry at Dartmouth College, Hanover, USA. His research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Prof Gribble also has a deep interest in ...
Format:PaperbackDimensions:658 pages, 9.45 × 6.5 × 0.68 inPublished:December 19, 2006Publisher:Elsevier Science & TechLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080451179

ISBN - 13:9780080451176

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Table of Contents

Chapter 1: Introduction
Chapter 2: Pyrroles
Chapter 3: Indoles
Chapter 4: Pyridines
Chapter 5: Thiophenes and Benzo[b]thiophenes
Chapter 6: Furans and Benzo[b]furans
Chapter 7: Thiazoles and Benzothiazoles
Chapter 8: Oxazoles and Benzoxazoles
Chapter 9: Imidazoles
Chapter 10: Pyrazines and Quinoxalines
Chapter 11: Pyrimidines
Chapter 12: Quinolines
Chapter 13: Pyridazines
Chapter 14: Industrial Scale Palladium Chemistry