Pancreas, Islet and Stem Cell Transplantation for the Cure of Diabetes

Hardcover | August 21, 2010

EditorNadey S. Hakim, Robert J. Stratta, Derek Gray

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Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreastransplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life. This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantationand islet and pancreatic stem cell transplantation.

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Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreastransplantation however must be balanced against the risk...

Nadey S. Hakim is Consultant in General Surgery at Hammersmith Hospital, London, UK. Robert J. Stratta is Professor of Surgery and Director of Transplantation at Wake Forest University School of Medicine, USA. Derek Gray is Professor of Experimental Surgery in the Nuffield Department of Surgery at the University of Oxford, UK. Peter ...

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Format:HardcoverDimensions:582 pagesPublished:August 21, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199565864

ISBN - 13:9780199565863

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Table of Contents

1. The history of pancreas transplantation2. The nature of the problem: why do we need pancreatic transplantation?3. Experimental models in whole organ pancreatic transplantation4. Indications, patient evaluation and selection5. Donor management and selection in pancreas transplantation6. Procurement and benchwork preparation of the pancreatic graft7. Pancreas preservation8. Surgical techniques of pancreas transplantation9. Immunosuppression for pancreas transplantation10. Pancreatic rejection: histology, diagnosis and treatment11. Surgical complications of pancreas transplantation12. Medical and urological complications of pancreas and kidney/ pancreas transplantation13. Post-transplant glucose intolerance14. Long term metabolic and other consequences of pancreas and islet transplantation15. Quality issues in pancreas transplantation16. Pancreas transplantation using living donors17. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR)18. Insulin Gene Therapy19. A historical view for the development of cellular and islet transplantation20. Fetal and neonatal pancreatic tissue transplantation21. Experimental approaches to the prevention of islet rejection22. Suitable donor selection, techniques of islet isolation and purification for human islet allograft transplantation23. Outcomes and clinical effectiveness of islet transplantation24. Islet auto-transplantation25. Approaches to immunological tolerance and potential application in pancreatic islet transplantation26. History of pancreatic stem cell transplantation and alternative islet sources27. Stem cell therapy for the treatment of diabetes28. Future challenges in Beta cell replacement therapies29. Beta cell regenearation in the post-natal pancreas30. Gene and stem cell therapy for diabetes