Pancreatic Cancer by Andrew M. LowyPancreatic Cancer by Andrew M. Lowy

Pancreatic Cancer

EditorAndrew M. Lowy, Steven D. Leach, Philip Philip

Hardcover | August 25, 2008

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Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.

Details & Specs

Title:Pancreatic CancerFormat:HardcoverDimensions:762 pages, 9.25 × 6.1 × 0 inPublished:August 25, 2008Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387692509

ISBN - 13:9780387692500

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Extra Content

Table of Contents

Series Preface.- Preface.- Section I: Molecular Pathology and Epidemiology.- Spectrum of human pancreatic neoplasia.- Molecular genetics of human pancreatic cancer.- Pancreatic intraepithelial neoplasia: Intraductal papillary mucinous neoplasia.- Familial Pancreatic Familial Chronic Pancreatitis and Pancreatic Cancer Risk.- Section II: Pancreatic Cancer Biology.- Pancreatic stem cells: injury and regeneration.- Pancreatic developmental biology.- Experimental systems for pancreatic cancer research.- Kras-based mouse models.- Cell signaling pathways in pancreatic cancer.- Pancreatic cancer genomics and proteomics.- Section III: Pancreatic Cancer Staging.- Radiologic Staging.- The Role of PET scanning in Pancreatic Cancer.- Endoscopic Ultrasound Staging.- Laparoscopic Staging.- Section IV: Surgery for Pancreatic Cancer.- Pancreaticoduodenectomy: Past to Present.- Total Pancreatectomy.- Distal Pancreatectomy.- Vascular Resection for Pancreatic Cancer.- Management of Postoperative Complications following pancreaticoduodenectomy.- Controversies in surgical management of pancreatic cancer.- Regionalization.- Laparoscopic Resection.- Surgical management of IPMN.- Section V: Palliation of Pancreatic Cancer.- Cancer Pain and symptom management- drug therapy.- Supportive Care: cachexia, anorexia syndrome.- Endoscopic Palliation.- Section VI: Multimodality Therapy of Pancreatic Cancer.- State of the art in radiation therapy for pancreas cancer.- Role of radiosensitizers in the therapy of pancreas cancer.- Optimum cytotoxic therapy for advanced pancreas cancer.- Recent advances in adjuvant therapy for pancreas cancer.- Neoadjuvant therapy for resectable pancreas cancer.- Role of the pathologist in optimizing therapy for pancreas cancer.- Section VI. Emerging Targeted Therapies.- An overview of the molecular targets for new drug development.- The convergence of therapeutic and preventive strategies for pancreas cancer.- Utility of animal models in drug development.- Targeting the K-Ras oncogene.- HER family of receptors as treatment targets.- GSK3B and protein kinase C as potential targets.- Anti-angiogenesis strategies.- Strategies to reduce the activation of NFkB.- Combined approaches to targeted therapies.- Development of vaccine therapy for pancreas cancer.- Modulation of radiation therapy with targeted agents.- Incorporation of genomics and proteomics in drug development.- Pitfalls in the design of clinical trials and future directions.- Index.

Editorial Reviews

From the reviews:"The summary of models of pancreatic cancer is simple and would be valuable for readers who are beginning to work in the field. The review of studies in molecular signaling, genomics, and proteomics is a comprehensive introduction for clinicians who are interested in the biology of this disease. . provide a very good introduction for the clinician or the young investigator who is interested in the subject. . Clinician-investigators would be well served to read this as a review . ." (Murray F. Brennan, The New England Journal of Medicine, April, 2009)