PANCREATIC CANCER by John P. NeoptolemosPANCREATIC CANCER by John P. Neoptolemos


EditorJohn P. Neoptolemos, Raul A. Urrutia, James Abbruzzese

Hardcover | January 22, 2010

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This handbook details advances in pancreatic cancer research that have a profound and lasting impact on the field. It features the work of authors who are the very best in their respective fields and will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.
John Neoptolemos is Professor of Surgery and Head of the Division of Surgery and Oncology at the University of Liverpool and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. As an undergraduate he studied Natural Sciences at Cambridge (BA 1973, MA 1976) before completing his clinical undergraduate training at Guy...
Title:PANCREATIC CANCERFormat:HardcoverDimensions:1419 pagesPublished:January 22, 2010Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387774971

ISBN - 13:9780387774978

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Table of Contents

Section One: The Nature of Pancreatic Cancer Epidemiology: world overview, risk factors, prospects for preventionDevelopment and structure of pancreasPathologic classification and biological behaviour of pancreatic neoplasiaDevelopmental molecular biology of the pancreasMolecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancerMolecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, NeurofibromatosisSporadic neuroendocrine pancreatic tumoursMolecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancerMiscellaneous non-pancreatic non-endocrine tumoursNovel molecular relationships between chronic pancreatitis and cancerPancreatic cancer stem cellsCell cycle control: signalling pathways in pancreatic pathogenesisApoptosis: signalling pathways in pancreatic pathogenesisEGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK Hedgehog: signalling pathways in pancreatic pathogenesisSmad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesisNotch signalling in pancreatic morphogenesis and pancreatic cancerMolecular characterization of pancreatic cell linesMouse models of exocrine pancreatic cancer Principles and applications of microarray gene expression in pancreatic cancerPrinciples and applications of proteomics in pancreatic cancer Tumour-stromal interaction: invasion and metastasesGenetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromesInherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1 Section Two: Clinical Management of Pancreatic CancerClinical decision making in pancreatic cancerParaneoplastic syndromesDiagnostic and therapeutic response markersCT and fusion PET-CT Diagnosis, staging, and follow-upMRI and MRCP: diagnosis and staging of pancreatic cancerEUS Diagnosis and stagingLaparoscopy and laparoscopic ultrasound: diagnosis and stagingOverview of palliative management for pancreatic cancerEndoscopy.Interventional radiology Role of palliative surgery in advanced pancreatic cancerChemotherapy for advanced pancreatic cancer Developments in chemoradiation in advanced pancreatic cancerSurgical resection for pancreatic cancer Role of venous resection in pancreatic cancer surgeryPathological reporting and staging following resectionJapanese Pancreas Society staging for pancreatic cancerAdjuvant chemotherapy in pancreatic cancerCase for adjuvant chemoradiation therapy for pancreatic cancerCase for neoadjuvant treatment in pancreatic cancerBorderline resectable diseaseManagement of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasmsLaparoscopic surgery for pancreatic neoplasmModern Japanese approach to pancreas cancer Section Three: New DirectionsDevelopment of novel biomarkersInherited genetics of pancreatic cancer and secondary screeningGene therapy for pancreatic cancerVaccine therapy and immunotherapyEmerging targets in pancreatic cancer