Paraneoplastic Syndromes

Hardcover | September 5, 2011

byRobert B. Darnell, Jerome B. Posner

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Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and othersymptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The section discusses the clinical findings and treatment of individualparaneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplasticsyndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.

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Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and othersymptoms in patients suffered from occult or c...

Dr. Darnell studied neurology as Chief Resident with Dr. Fred Plum at The New York Hospital, Cornell, and then, beginning in 1990 and continuing through the present time, with Dr. Jerome Posner at Memorial Sloan-Kettering Cancer Center. Dr. Darnell is currently the Heilbrunn Cancer Professor and Senior Physician at The Rockefeller Univ...

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Format:HardcoverDimensions:496 pages, 7.4 × 10.2 × 1.18 inPublished:September 5, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199772738

ISBN - 13:9780199772735

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Table of Contents

OVERVIEW1. HISTORY2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS3. PATHOGENESIS4. BRAIN (CEREBRUM5. BRAIN (CEREBELLUM AND BRAINSTEM)6. SPINAL CORD7. CRANIAL NERVES8. DORSAL ROOT GANGLIA AND PERIPHERAL NERVES9. NEUROMUSCULAR JUNCTION AND MUSCLE10. SYSTEMIC SYNDROMES (WITH NEUROLOGIC IMPLICATIONS)11. NUCLEAR/NUCLEOLAR ANTIBODIES12. CYTOPLASMIC ANTIBODIES13. SYNAPTIC/CHANNEL ANTIBODIES14. ANTI-RETINAL/OPTIC NERVE ANTIBODIES15. THORACIC CANCERS16. BREAST/GYNECOLOGIC/TESTICULAR CANCER17. HEMATOLOGIC CANCERS/MISCELLANEOUS SOLID TUMORS