Patient Derived Tumor Xenograft Models: Promise, Potential And Practice

Paperback | November 1, 2016

byRajesh UthamanthilEditorPeggy Tinkey, Elisa De Stanchina

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Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

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Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growi...

Dr. Rajesh Uthamanthil is the director of Comparative Medicine program at Fred Hutchinson Cancer Research Center, Seattle, WA. He received Doctorate in Veterinary Medicine and Veterinary Sciences from Kerala Agricultural University, PhD in Comparative Biosciences from the University of Wisconsin Madison and completed a post doctoral fe...
Format:PaperbackDimensions:486 pages, 8.75 × 6.35 × 0.68 inPublished:November 1, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128040106

ISBN - 13:9780128040102

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Table of Contents

Section I. Mouse Xenograft Models of Cancer 1. PDX models - History and Advantages 2. History of Mouse Cancer Models 3. Challenges and limitations of mouse xenograft cancer models 4. Tumor heterogeneity 5. Immunocompromised mice - the back bone of PDX models 6. Humanized mice and PDX models

Section II. Components of a PDX program 1. Meeting the regulatory requirements 2. Tumor/clinical sample acquisition and storage 3. Methodology for developing and maintaining the PDX mouse model 4. Pathology of the PDX tumors 5. Profiling tumors in PDX models 6. Running a PDX core/support program 7. Veterinary Care 8. Occupational Health and Safety

Section III. PDX models for tumors of various organ systems 1. PDX models of Brain Tumors 2. PDX models of Prostate Tumors 3. PDX models of Pancreatic Tumors 4. PDX models of Breast Tumors 5. PDX models of Ovarian/Gyenocologic Tumors 6. PDX models of Lung Tumors 7. PDX models of Colorectal Tumors 8. Liquid tumors 9. PDX Models of Melanoma 10. Ex vivo 3D modeling of PDX tumors

Section IV. PDX models in cancer research and therapy around the world 1. Role of Academic institutions in development and support of PDX models 2. Role of Industry in development and support of PDX models

Section V. Challenges & Future of PDX Models 1. Challenges in PDX models 2. Controlling variability in PDX models 3. Future of PDX models