Peptide-Based Drug Design by Laszlo OtvosPeptide-Based Drug Design by Laszlo Otvos

Peptide-Based Drug Design

EditorLaszlo Otvos

Paperback | November 19, 2010

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Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyT series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
Title:Peptide-Based Drug DesignFormat:PaperbackDimensions:316 pages, 9.25 × 6.1 × 0.07 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617378690

ISBN - 13:9781617378690

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Table of Contents

1 Peptide-based Drug Design: Here and NowLaszlo Otvos, Jr.2 Strategies for the Discovery, Isolation, and Characterization of Natural Bioactive Peptides from the Immune System of InvertebratesPhilippe Bulet3 Sequence Analysis of Antimicrobial Peptides by Tandem Mass SpectrometryChristin Stegemann and Ralf Hoffmann4 The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose MembranesDirk F.H. Winkler and William D. Campbell5 Analysis of Abeta interactions using ProteinChip Technology Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P. Smith, Kevin J. Barnham, and John D. Wade6 NMR in Peptide Drug DevelopmentJan-Christoph Westermann and David J Craik7 Molecular Dynamics Simulations of Peptides Jeffrey Copps, Richard F. Murphy, and Sándor Lovas 8 Short Linear Cationic Antimicrobial Peptides - Screening, Optimizing and Prediction Kai Hilpert, Christopher D Fjell, and Artem Cherkasov9 Investigation of the Mode of Action of Proline-rich Antimicrobial Peptides: Genetic and Cytometric Approaches.Marco Scocchi, Maura Mattiuzzo, Monica Benincasa, Nikolinka Antcheva, Alessandro Tossi, and Renato Gennaro10 Serum Stability of PeptidesHåvard Jenssen and Stein Ivar Aspmo11 Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase AssemblyMare Cudic and Gayle D. Burstein12 Synthesis of O-Phosphopeptides on Solid PhaseDavid Singer and Ralf Hoffmann13 Peptidomimetics: Fmoc Solid-Phase Pseudopeptide SynthesisPredrag Cudic and Maciej Stawikowski 14 Synthesis of Toll-like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting VaccinesBrendon Y. Chua, Weiguang Zeng & David C. Jackson15 Synthesis of a Multivalent, Multiepitope Vaccine ConstructLaszlo Otvos, Jr.16 Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting ProteinsMarina V. Backer, Zoia Levashova, Richard Levenson, Francis G. Blankenberg, and Joseph M. Backer