Peptide-Lipid Interactions

Other | March 1, 2002

bySimon, Sidney A., Sidney A. Simon

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This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.

Key Features
* world-renowned experts
* state-of-the-art experimental methods
* monolayers, bilayers, biological membranes
* theoretical aspects and computer simulations
* rafts
* synaptic transmission
* membrane fusion
* signal transduction

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From the Publisher

This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quen...

Format:OtherDimensions:601 pages, 1 × 1 × 1 inPublished:March 1, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080490964

ISBN - 13:9780080490960

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Table of Contents

PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions
Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling.
Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes.
Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous
Monolayers.
Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence
Quenching.
Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model
membranes and Lipid/Peptide Interactions.
Lipid-Peptide Interactions Investigated by NMR.
Peptide-Lipid Interactions in Supported Monolayers and Bilayers.

Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions
Free Energy Determinants of Peptide Association with Lipid Bilayers.
Investigating Ion Channels Using Computational Methods.

Part III: Experimental Investigations of Peptide-Lipid Interactions
The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes.
The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol.
Transmembrane Alpha Helices.
Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins.
Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces.
Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability.
The Hydrophobicity Threshold for Peptide Insertion into Membranes.

Part IV: Specialized Topics of Biological Relevance
Signal Sequence Function in the Mammalian Endoplasmic Reticulum: A Biological Perspective.
The Process of Membrane Fusion: Nipples, Hemifusion Pores, and Pore Growth.
Prenylation of CaaX-Type Proteins: Basic Principles through Clinical Applications.
Peptides as Probes of Protein-Protein Interactions Involved in Neurotransmitter Release.