Peripheral Neuropathies in Clinical Practice by Steven HerskovitzPeripheral Neuropathies in Clinical Practice by Steven Herskovitz

Peripheral Neuropathies in Clinical Practice

bySteven Herskovitz, Stephen Scelsa, Herbert Schaumburg

Hardcover | March 11, 2010

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The last 2 decades have seen enormous strides in our understanding of the biological, genetic and clinical basis of the peripheral nerve disorders. This remains a difficult area for most practitioners. This text combines a thorough review of the neurologic literature with clinical experiencein presenting a comprehensive yet concise and readable approach to the understanding, evaluation and management of these disorders. All practitioners seeing these patients, as well as all trainees in Neurology and related fields, should find this a useful, approachable initial resource.
Steven Herskovitz is Professor of Clinical Neurology and Director of the Neuromuscular Division and EMG Lab, Montefiore Medical Center/Albert Einstein College of Medicine. Stephen Scelsa is Associate Professor of Clinical Neurology, Montefiore Medical Center/Albert Einstein College of Medicine. Herbert Schaumburg is Professor of Neurol...
Title:Peripheral Neuropathies in Clinical PracticeFormat:HardcoverDimensions:416 pages, 10 × 7.2 × 1.1 inPublished:March 11, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195183266

ISBN - 13:9780195183269


Table of Contents

1. Basic Concepts and Glossary of Common Clinical TermsDefinition of the Peripheral Nervous System (PNS)Relationships Fundamental to an Understanding of Disease of Peripheral Nerve FibersNeuron Cell Body and AxonAxon, Schwann Cell and MyelinAxon and End OrganWallerian Degeneration and Axon RegenerationGlossary of Common Clinical Terms2. Anatomic Classification of Peripheral Nervous System DisordersSymmetric Generalized Neuropathies (Polyneuropathies)Distal Axonal DegenerationSegmental (Non-Uniform) MyelinopathyDiffuse (Uniform) MyelinopathyNeuronopathy (Ganglionopathy)Focal (Mononeuropathy) and Multifocal (Multiple Mononeuropathy) NeuropathiesIschemiaInfiltrationPhysical Injuries3. Evaluation and Management of the Patient with Peripheral NeuropathyGeneral Principles and the Algorithmic ApproachChronic Idiopathic Axonal Polyneuropathy / Small Fiber NeuropathyTreatment of Neuropathic PainDifferential Diagnoses and Work-ups for the Varied Neuropathy Phenotypes (Tables)Sensorimotor Polyneuropathies - AxonalSensorimotor Polyneuropathies - Demeyelinating or MixedSensory, Small Fiber, Painful PolyneuropathiesSensory, Large Fiber, Ataxic PolyneuropathiesMotor NeuropathiesAutonomic NeuropathiesMononeuropathy MultiplexMyeloneuropathiesNeuromyopathiesPolyneuropathy and Optic NeuropathyPolyradiculopathiesPlexopathies/RadiculoplexopathiesFacial NeuropathyTrigeminal Sensory NeuropathyUnusual Neuropathy Patterns4. Electrodiagnostic, Imaging, Nerve and Skin Biopsy Investigations in Peripheral Nerve DiseaseElectromyography and Nerve Conduction StudiesSensory Nerve Conduction StudiesMotor Nerve Conduction StudiesLate ResponsesBlink Reflex StudiesNeedle ElectromyographyStudies of Autonomic FunctionQuantitiative Sudomotor Axon Reflex TestThermoregulatory Sweat TestHeart Rate Response to Deep BreathingValsalva ManeuverQuantitative Sensory TestingDeveloping Electrophysiologic and Imaging TechniquesMotor Unit Number EstimationElectrical Impedence MyographyHigh-Resolution Sonography of Peripheral NerveMagnetic Resonance NeurographyMuscle MRIPositron Emission TomographyNerve BiopsySkin Biopsy5. Case Presentations Illustrating the Diagnostic MethodCase 1: Painful small fiber neuropathy and dysautonomiaCase 2: Insidious onset of distal weakness in an adult with deformed feetCase 3: Lower limb paresthesias in a middle-aged adult with diabetesCase 4: A middle-aged woman with muscle twitching and episodic numbnessCase 5: Six days of cranial neuropathies and hyporeflexiaCase 6: A two-month onset of sensory neuropathy in a woman with ovarian carcinomaCase 7: A 47-year-old man with 10 years of progressive bilateral hand weaknessCase 8: Chronic sensory loss and unsteady gait in a 59-year-old womanCase 9: An elderly man with acral paresthesias and gait unsteadinessCase 10: Foot drop in an 81-year-old womanCase 11: A middle-aged man with multifocal pain, sensory loss and weaknessCase 12: Five-day onset of diffuse weakness6. Acute Immune-mediated NeuropathiesDemyelinating Immune-mediated NeuropathiesAcute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP) and Fisher Syndrome (FS)Axonal Immune-mediated NeuropathiesAcute Motor Axonal Neuropathy (AMAN) and Acute Motor and SensoryAxonal Neuropathy (AMSAN)NeuronopathiesSensory (Idiopathic, Sjogren Syndrome, Paraneoplastic) and Motor (Paraneoplastic) Neuronopathies and Autoimmune Autonomic Ganglionopathy7. Chronic Immune-mediated NeuropathiesChronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)CIDP Variants:Multifocal Motor Neuropathy with Conduction Block (MMN)Lewis-Sumner Syndrome (LSS)/Multifocal Acquired Demyelinating Sensory and Motor Neuropathy (MADSAM)Distal Acquired Demyelinating Symmetric Neuropathy (DADS)CIDP with CNS FeaturesChronic Immune Sensory Polyradiculopathy (CISP)Chronic Sensory Demyelinating Polyneuropathy8. Neuropathies Associated with Monoclonal Gammopathies and CancerMultiple MyelomaOsteosclerotic MyelomaPrimary Systemic Amyloidosis (AL Amyloidosis)Waldenstrom MacroglobulinemiaMonoclonal Gammopathy of Undetermined Significance9. Infectious and Granulomatous NeuropathiesHerpes Zoster/Herpes SimplexLeprosySarcoidosisLyme DiseaseHIVHepatitis C/CryoglobulinemiaDiphtheria10. Diabetic and Other Endocrine NeuropathiesDiabetic NeuropathiesDistal Symmetric Sensorimotor/Autonomic PolyneuropathyProximal Multifocal NeuropathiesLumbosacral Radiculoplexus NeuropathyThoracolumbar "Truncal" RadiculoneuropathyFocal Limb Neuropathies (Entrapment Sites)Isolated Cranial NeuropathiesAcute Painful Neuropathy ("Diabetic Neuropathic Cachexia")Diabetic Motor-predominant NeuropathiesTreatment-induced Neuropathy ("Insulin Neuritis")Hyperglycemic NeuropathyAcromegalic NeuropathyHypothyroid Neuropathy11. Neuropathies Associated with Vitamin Deficiencies and MalabsorptionVitamin B12 (Cobalamin) DeficiencyVitamin B1 (Thiamine) DeficiencyCeliac DiseaseVitamin E (?-tocopherol) DeficiencyCopper DeficiencyOther: Cuban Epidemic Optic and Peripheral Neuropathy; Deficiencies: Riboflavin (B2), Pyridoxine (B6), Folate, Zinc; Bariatric Surgery12. Vascular/Ischemic NeuropathiesVasculitic NeuropathiesNeuropathies Associated with Peripheral Arterial Occlusive DiseaseNeuropathies Associated with Compartment Syndromes13. Neuropathies Associated with Organ FailurePulmonary FailureHepatic FailureRenal FailureUremic PolyneuropathyMononeuropathiesIschemic Monomelic NeuropathyOrgan TransplantationCritical Illness PolyneuropathyDifferential Diagnosis14. The Hereditary NeuropathiesHereditary Motor and Sensory NeuropathiesCharcot-Marie Tooth Disease, Type 1Hereditary Neuropathy with Liability to Pressure PalsyCharcot-Marie Tooth Disease, Type 2Dejerine-Sottas Disease/Congenital Hypomyelinating NeuropathyCharcot-Marie Tooth Disease, Type 4Charcot-Marie Tooth, Type XCharcot-Marie-Tooth Disease-Dominant IntermediateHereditary Sensory and Autonomic NeuropathiesDistal hereditary Motor Neuropathy/NeuronopathyHereditary Ataxia with NeuropathyAutosomal DominantAutosomal RecessiveX-linkedHereditary Spastic Paraplegia with NeuropathyHereditary Brachial Plexus Neuropathy/Hereditary Neuralgic AmyotrophyHereditary Peripheral Nerve ChannelopathiesSodium ChannelopathiesPotassium Channelopathies15. Hereditary Metabolic/Multisystem Disorders with NeuropathyFamilial Amyloid PolyneuropathiesDisorders of Lipid MetabolismLysosomal DisordersFabry DiseaseLeukodystrophiesMetachromatic LeukodystrophyKrabbe DiseasePeroxisomal DisordersRefsum DiseaseAdrenomyeloneuropathyLipoprotein DeficienciesTangier DiseaseAbetalipoproteinemiaFamilial HypobetalipoproteinemiaCerebrotendinous XanthomatosisDisorders of Heme Metabolism - PorphyriaDisorders of Defective DNA RepairMitochondrial DisordersNeuroacanthocytosis SyndromesChorea-AcanthocytosisMcLeod SyndromeNeurofibromatous NeuropathyGlycogen Storage DiseasesAdult Polyglucosan Body Disease16. The Toxic Neuropathies: Principles of General and Peripheral Neurotoxicology; Pharmaceutical AgentsPrinciples of General NeurotoxicologyPrinciples of Peripheral NeurotoxicologyPeripheral Neurotoxicity Associated with Pharmaceutical Agents17. The Toxic Neuropathies: Industrial, Occupational and Environmental AgentsPeripheral Neurotoxicity Associated with Industrial, Occupational and Environmental Agents18. Focal neuropathies: Nerve injuries, Entrapments and Other MononeuropathiesNerve InjuriesAnatomy and Pathophysiology of Nerve InjuriesClinical Classification or Nerve InjuriesElectrodiagnostic Features of Nerve InjuriesNerve Regeneration and RepairFocal Neuropathies: The Upper ExtremityMedian NerveUlnar NerveRadial NerveOther Upper Extremity MononeuropathiesFocal Neuropathies: The Lower ExtremitySciatic nervePeroneal NerveTibial NerveFemoral NerveLateral Femoral Cutaneous NerveOther Lower Extremity MononeuropathiesFocal Neuropathies: Cranial NeuropathiesIdiopathic Facial Nerve Paralysis (Bell's palsy)19. PlexopathiesBrachial PlexopathyAnatomyEtiologyTraumaThoracic Outlet SyndromeNeoplastic Brachial PlexopathyRadiation-induced Brachial PlexopathyImmune Brachial Plexus Neuropathy (Neuralgic Amyotrophy)Lumbosacral PlexopathyAnatomyEtiologyTrauma and IschemiaRetroperitoneal HemorrhageNeoplastic Lumbosacral PlexopathyRadiation-induced Lumbosacral PlexopathyNon-diabetic Lumbosacral Radiculoplexus Neuropathy20. Disorders of Peripheral Nerve HyperexcitabilityGeneralizedNeuromyotoniaCrampsFasciculationsTetanyLocalizedFacial MyokymiaLocalized or Focal MyokymiaHemifacial SpasmHemimasticatory SpasmHypothenar DimplingIndex