Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery by Konstantin V. BalakinPharmaceutical Data Mining: Approaches and Applications for Drug Discovery by Konstantin V. Balakin

Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery

byKonstantin V. BalakinEditorSean Ekins

Hardcover | December 21, 2009

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Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development

In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover:

  • A general overview of the discipline, from its foundations to contemporary industrial applications
  • Chemoinformatics-based applications
  • Bioinformatics-based applications
  • Data mining methods in clinical development
  • Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches

In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.

Konstantin V. Balakin is Head of the Laboratory of Information Technology in Medicinal Chemistry at the Institute of Physiologically Active Compounds at the Russian Academy of Sciences. He is also Director of the scientific consortium "Orchemed" (Organic Chemistry and Medicine), which currently includes 11 Russian academic institutes w...
Title:Pharmaceutical Data Mining: Approaches and Applications for Drug DiscoveryFormat:HardcoverDimensions:565 pages, 9.55 × 6.35 × 1.2 inPublished:December 21, 2009Publisher:WileyLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0470196084

ISBN - 13:9780470196083

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Table of Contents

Preface.

Acknowledgments.

Contributors.

PART I: DATA MINING IN THE PHARMACEUTICAL INDUSTRY: A GENERAL OVERVIEW.

1 A History of the development of Data Mining in Pharmaceutical Research ( David J. Livingstone and John Bradshaw).

2 Drug Gold and Data Dragons: Myths and Realities of Data Mining in the Pharmaceutical Industry (Barry Robson and Andy Vaithiligam).

3 Application of Data Mining Algorithms in Pharmaceutical Research and Development (Konstantin V. Balakin and Nikolay P. Savchuk).

PART II: CHEMOINFORMATICS-BASED APPLICATIONS.

4 Data Mining Approaches for Compound Selection and Iterative Screening (Martin Vogt and Jurgen Bajorath).

5 Prediction of Toxic Effects of Pharmaceutical Agents (Andreas Maunz and Christoph Helma).

6 Chemogenomics-Based Design of GPCR-Targeted Libraries Using Data Mining Techniques (Konstantin V. Balakin and Elena V. Bovina).

7 Mining High-Throughput Screening Data by Novel Knowledge-Based Optimization Analysis (S. Frank Yan, Frederick J. King, Sumit K. Chanda, Jeremy S. Caldwell, Elizabeth A. Winzeler, and Yingyao Zhou).

PART III: BIOINFORMATICS-BASED APPLICATIONS.

8 Mining DNA Microarray Gene Expression Data (Paolo Magni).

9 Bioinformatics Approaches for Analysis of Protein-Ligand Interactions (Munazah Andrabi, Chioko Nagao, Kenji Mizuguchi, and Shandar Ahmad).

10 Analysis of Toxicogenomic Databases (Lyle D. Burgoon).

11 Bridging the Pharmaceutical Shortfall: Informatics Approaches to the Discovery of Vaccines, Antigens, Epitopes, and Adjuvants (Matthew N. Davies and Darren R. Flower).

PART IV: DATA MINING METHODS IN CLINICAL DEVELOPMENT.

12 Data Mining in Pharmacovigilance (Manfred Hauben and Andrew Bate).

13 Data Mining Methods as Tools for Predicting Individual Drug Response (Audrey Sabbagh and Pierre Darlu).

14 Data Mining Methods in Pharmaceutical Formulation (Raymond C. Rowe and Elizabeth A Colbourn).

PART V: DATA MINING ALGORITHMS AND TECHNOLOGIES.

15 Dimensionality Reduction Techniques for Pharmaceutical Data Mining (Igor V. Pletnev, Yan A. Ivanenkov, and Alexey V. Tarasov).

16 Advanced Artificial Intelligence Methods Used in the Design of Pharmaceutical Agents (Yan A. Ivanenkov and Ludmila M. Khandarova).

17 Databases for Chemical and Biological Information (Tudor I. Oprea, Liliana Ostopovici-Halip, and Ramona Rad-Curpan).

18 Mining Chemical Structural Information from the Literature (Debra L. Banville).

Index.