Pharmacogenetics by Wendell WeberPharmacogenetics by Wendell Weber


byWendell Weber

Hardcover | April 6, 2008

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Genes are important modifiers of the human response to drugs, hormones, and toxins. Medical patients and healthy individuals alike display significant differences in response and suffer adverse effects as a result of exposure to many therapeutic agents and occupational chemicals. In thissubstantially revised second edition, highly regarded authority Wendell Weber brings together laboratory methods and epidemiologic studies in defining the role of heredity in human drug response. The book is divided into two major sections, one covering pharmacognetic concepts and the second theapplication of those concepts. The first edition was published in 1997, and a vast amount of new information about the genetics of human drug response has accumulated since then. In just five years, we have moved from mapping the first complete sequence of a free-living organism to a working draft of the human genome. Theapplication of tools for analyzing genetic variation and the maturation of the human genome initiative has provided a wealth of primary genetic information and functional genomic data to fuel our understanding of genetic variation. Today, pharmacogenetics comprises a well-integrated network ofphysicians and scientists worldwide who are attempting to identify variations in human disease and drug response and how they might use this information to discover new, more effective drugs and avoid unwanted drug responses.
Title:PharmacogeneticsFormat:HardcoverDimensions:416 pages, 9.25 × 6.13 × 2.5 inPublished:April 6, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195341511

ISBN - 13:9780195341515


Table of Contents

1. Beginnings Cellular Foundations of Early Pharmacology and Genetics Molecular Foundations of Early Pharmacology and Genetics The Emergence of Modern Genetics and Experimental Pharmacogenetics The Genomics Era The Effect of Molecular Biology on Pharmacogenetics2. Defining Pharmacogenetics The Genetic Profile of Human Drug Response Evidence for Individual Variation in Drug Response Evidence that Individual Variation is Inherited Interaction with Other Fields Empowers Pharmacogenetics Pharmacogenetics is Park of EcogeneticsStrategies for Gene Identification The Outlook for Pharmacogenetics SummaryFundamentals3. Pharmacology of Human Drug Response Pharmacology and Genetics of Human Drug Response are Complementary Pharmacogenetics Dose Response Relationships Pharmacokinetics in Pharmacogenetics Pharmacogenetic Mechanisms of Human Drug Response Testing Pharmacogenetic Hypotheses Summary4. Age-related Pharmacology Age-related Physiologic Variation Pharmacokinetic Variation Pharmacodynamic Variation Summary5. Genetics in Pharmacology More about Genetic Profiling Drug Response Twin Studies Family Studies Mathematical Treatment of Heterogeneity in Drug Response Impediments to Pharmacogenetic Investigation Summary6. Epigenetics The Emergence of Epigenetics The Foudnations of Epigenetics The Effect of Molecular Biology on Epigenetics Epigenetics in Health and Disease Therapeutic Potential for Epigenetic Disease Summary7. Genomic Tools Charting the Evolution of Genomic Tools Analytical Techniques Conventional Analysis of Genetic Variants Advances in Genomic Technology Emerging Technologies Summary8. Ethnic Pharmacogenetics Marrying Race and Ethnicity to Genetic Variation Ethnic Specificity in Drug Response Frequency of Pharmacogenetic Ethnic Specificities Ethnicity as a Starting Point for Pharmacogenetics Ethnicity in Drug Development Ethnic Research and Culturally Specific Risks Summary9. Modeling Human Drug Response Mouse Models of Pharmacogenetic Traits Constructing Inbred Mouse Models Gene Targeting Creating Mouse Models by Gene Targeting Quantitative Trait Locus Analysis Simple Eukaryotic Organisms as Experimental Models Summary

Editorial Reviews

.,."an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics."--Doody's