Pharmacogenomics and Personalized Medicine by Nadine CohenPharmacogenomics and Personalized Medicine by Nadine Cohen

Pharmacogenomics and Personalized Medicine

byNadine Cohen

Paperback | November 9, 2010

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With all the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities and obstacles in its application. Focusing on DNA data and associated analytical methodologies, with a consideration for complementary RNA-based studies, this volume includes a wide array of vital, cutting-edge research.Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of the current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.
Title:Pharmacogenomics and Personalized MedicineFormat:PaperbackDimensions:509 pages, 23.5 × 15.5 × 0.01 inPublished:November 9, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617379212

ISBN - 13:9781617379215

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Table of Contents

PrefaceContributors Challenges, Opportunities and Evolving Landscape in Pharmacogenomics and Personalized Medicine: An Industry PerspectiveNadine Cohen and Theresa Frangiosa Considerations for Sample Collections Intended for Pharmacogenomic analyses: The Pharmacogenomics protocol and informed consent form Deborah Ricci and Monique FrancPharmacogenomics: The Regulatory Environment and Labeling ImplicationMyong-Jin Kim, Shiew-Mei Huang, Atiqur Rahman, Felix W. Frueh, Lawrence J. LeskoApplications of Pharmacogenomics in Drug DiscoveryDuncan McHale Applications of Pharmacogenomics in Clinical TrialsMonique Franc Pharmacogenomics applications in drug metabolism: from genotyping to druglabel-challenges?Ann K. Daly The Genetics of Adverse Drug Reactions - Promises and ProblemsMartin Armstrong Strategies and resources for marker selection and genotyping in genetic association studiesNicole Soranzo, Dong-Jing Fu and Qingqin S. Li Study Design and Statistical Methods in Pharmacogenomics Research: From Candidate Genes to Genome Wide ScreensNicholas J. Schork, Nathalie Malo, Eric J. Topol Holy SNP, Batman! Reyna Favis Use of Predictive Biomarker Classifiers in the Design of Pivotal Clinical TrialsRichard Simon Translation of biomarkers into clinical utility William Trepicchio and George Mulligan Pharmacogenomic Study Feasibility Assessment and Pharmaceutical Business Decision-MakingMonique Franc and Theresa Frangiosa Co-development of drugs and Pharmacogenomics based Diagnostics in Oncology Jeffrey RossPharmacogenomics applications in Epilepsy Chantal Depondt Pharmacogenomics in Alzheimer's DiseaseRamon Cacabelos Pharmacogenomics applications in Psychiatric disorders Todd Lencz and Anil K. MalhotraPharmacogenomics in HIV DiseaseAmalio TelentiPharmacogenomics and Cardiovascular Drugs Gérard Siest, Hind Berrahmoune, Jean-Brice Marteau,and Sophie Visvikis-SiestPharmacogenomic applications in Children Struan F.A. Grant and Hakon Hakonarson Pharmacogenomics of rare and monogenic disorders Paul Maher

Editorial Reviews

From the reviews:"The purpose is to provide a practical and integrative view of the application of pharmacogenomics to personalized medicine. . the information is valuable for scientists in academic, industrial, and healthcare areas who are striving to transform the current practice of medicine into personalized medicine. . this one provides the most comprehensive discussion on how to apply pharmacogenomics to attain greater success in bringing personalized medicine to clinical practice." (Xiaobo Zhong, Doody's Review Service, January, 2009)