Pharmacogenomics: Methods and Protocols by Federico InnocentiPharmacogenomics: Methods and Protocols by Federico Innocenti

Pharmacogenomics: Methods and Protocols

EditorFederico Innocenti

Paperback | November 19, 2010

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Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
Title:Pharmacogenomics: Methods and ProtocolsFormat:PaperbackDimensions:224 pages, 9.02 × 5.98 × 0 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375713

ISBN - 13:9781617375712

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Table of Contents

Part I. History and OverviewPharmacogenomics: Historical Perspective and Current StatusWerner KalowPart II. Functional Analysis of Gene VariationTransfection Assays With Allele-Specific Constructs: Functional Analysis of UDP-Glucuronosyltransferase VariantsHideto Jinno, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Yoshiro Saito, Shogo Ozawa, and Jun-ichi SawadaSnapshot of the Allele-Specific Variation in Human Gene ExpressionHai YanGenome-Wide Analysis of Allele-Specific Gene Expression Using Oligo MicroarraysMaxwell P. LeeHaploChIP: An In Vivo AssayJulian Charles KnightPart III. Genotyping TechniquesAspects Influencing Genotyping Method SelectionPeter ImleDenaturing High-Performance Liquid Chromatography for Mutation Detection and GenotypingDonna Lee Fackenthal, Pei Xian Chen, and Soma DasPyrosequencing of Clinically Relevant PolymorphismsSharon Marsh, Cristi R. King, Adam A. Garsa, and Howard L. McLeodKinetic Fluorescence-Quenching Detection Assay for Allele Frequency EstimationMing Xiao and Pui-Yan KwokMatrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass SpectrometryMatthias Wjst and Dirk van den BoomFluorescence-Based Fragment Size AnalysisPeter ImleSingle-Nucleotide Polymorphism Genotyping in DNA PoolsIan Craig, Emma Meaburn, Lee Butcher, Linzy Hill, and Robert PlominTaqMan Genotyping of Insertion/Deletion PolymorphismsRenato Robledo, William R. Beggs, and Patrick K. BenderPart IV. Management of Pharmacogenomic InformationPharmGKB: The Pharmacogenetics and Pharmacogenomics Knowledge BaseCaroline F. Thorn, Teri E. Klein, and Russ B. AltmanSystems for the Management of Pharmacogenomic InformationAlexander Sturn, Michael Maurer, Robert Molidor, and Zlatko TrajanoskiIndex