Pharmacokinetic And Pharmacodynamic Drug Interactions Associated With Antiretroviral Drugs by Tony K. L. KiangPharmacokinetic And Pharmacodynamic Drug Interactions Associated With Antiretroviral Drugs by Tony K. L. Kiang

Pharmacokinetic And Pharmacodynamic Drug Interactions Associated With Antiretroviral Drugs

byTony K. L. KiangEditorKyle John Wilby, Mary H. H. Ensom

Hardcover | January 3, 2017

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Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers,  this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today. 

Dr. Mary H.H. Ensom (formerly Chandler) is Professor, Faculty of Pharmaceutical Sciences and Distinguished University Scholar, University of British Columbia (UBC) and Clinical Pharmacy Specialist, Children's & Women's Health Centre of British Columbia in Vancouver, Canada. Her research focuses on effects of various pathophysiologic st...
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Title:Pharmacokinetic And Pharmacodynamic Drug Interactions Associated With Antiretroviral DrugsFormat:HardcoverDimensions:135 pagesPublished:January 3, 2017Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9811021120

ISBN - 13:9789811021121

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Table of Contents

1. Introduction.- 2. HIV-Associated Comorbidities.- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals.- 4. In Vitro Reaction Phenotyping and Drug Interaction Data.- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents.- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs.- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents.- 8. Conclusion and Clinical Decision Algorithm.

Editorial Reviews

"Antiretrovirals are an unfamiliar topic to most clinicians not already immersed in the field. This is a thorough review of the available literature on each agent used against HIV regarding both their effects on other drugs as well as how other drugs affect them. . The book is geared towards student/resident learners who would like to understand the intricacies of antiretroviral pharmacokinetics/pharmacodynamics." (David E. Koren, Doody's Book Reviews, March, 2016)