Pharmacological Mechanisms in Alzheimer's Therapeutics by Claudio CuelloPharmacological Mechanisms in Alzheimer's Therapeutics by Claudio Cuello

Pharmacological Mechanisms in Alzheimer's Therapeutics

EditorClaudio Cuello

Paperback | October 29, 2010

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The need for effective therapy to treat Alzheimer's disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.
Title:Pharmacological Mechanisms in Alzheimer's TherapeuticsFormat:PaperbackDimensions:344 pages, 9.25 × 6.1 × 0 inPublished:October 29, 2010Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441924469

ISBN - 13:9781441924469

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Table of Contents

Overview of the Alzheimer's disease pathology and potential therapeutic targets.- Trial designs and outcomes to monitor novel therapeutics in alzheimer's disease.- The pharmacological treatment of Alzheimer's disease with cholinesterase inhibitors and memantine.- M1 Muscarinic Agonists.- Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy.- The rationale for glutamatergic therapy in Alzheimer's disease.- Secretases as pharmacological targets in Alzheimer's disease.- Secretase as a Target for Alzheimer's Disease.- The Rationale for an Immunological Approach to Alzheimer's Therapeutics.- Neuroinflammation, Alzheimer Disease and Other Aging Disorders.- Non-steroidal anti-inflammatory drugs (NSAIDs) and derived A42-lowering molecules for treatment and prevention of Alzheimer's disease (AD).- The potential application of antioxidant agents in Alzheimer disease therapeutics.- Apolipoprotein E: a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease.- Tau Pathology as a Target In Alzheimer's Therapeutics.- Design of inhibitors of Amyloid-beta misfolding and aggregation for Alzheimer's Therapy.- Potential applications of glycosaminoglycan-related compounds in Alzheimer's disease.- Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease.- Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's disease.