Pharmacology of Cytokines

Paperback | September 7, 2000

byAlberto Mantovani, Charles A. Dinarello, Pietro Ghezzi

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Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role inhomeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents,has been the object of intense and competitive research. The pharmacology of cytokines is an exploding area which is entering the clinical arena. This book gives an overview of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology ofcytokines, the book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products . In addition to examining individual agents and approaches, it reviews the pathophysiology of individual body systems and analysisspecific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.

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From the Publisher

Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role inhomeostasis and in host defence and are involved i...

Alberto Mantovani, M.D. is Head of the Department of Immunology and Cell Biology at the Instituto di Ricerche Farmacologiche 'Mario Negri' in Milan and Professor of General Pathology at the University of Brescia, Italy. Charles Dinarello is Professor and Head of the Division of Infectious Diseases at the University of Colorado Hea...

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Kobo ebook|Nov 12 2014

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Format:PaperbackPublished:September 7, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198500424

ISBN - 13:9780198500421

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Table of Contents

Preface1. Cytokines: a world apartPart I: Pharmacology2. Inhibitors of cytokine production and action3. Inhibitors of cytokine processing4. Receptor antagonists5. Antibodies and soluble receptors6. Anti-inflammatory/immunosupressive cytokinesPart II: Pharmacology in a context8. Nervous system9. Cardiovascular system10. Cancer11. Liver and lung12. Skin13. SepsisAppendix: Interferon Beta

Editorial Reviews

"This book provides a 'breath of fresh air' in an otherwise complicated area of Immunology. In conclusion the authors have managed to produce a concise, well researched and well organised book, which lives up to its aims, in doing so it provides a useful review of research efforts in cytokinepharmacology, as such the book is suitable for clinicians, research scientists and students of Immunology interested in cytokine pharmacology."Immunology News