Physics At The Biomolecular Interface: Fundamentals For Molecular Targeted Therapy by Ariel Fernández

Physics At The Biomolecular Interface: Fundamentals For Molecular Targeted Therapy

byAriel Fernández

Paperback | June 20, 2018

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This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics.

The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective.

The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.
Ariel Fernández (born Ariel Fernández Stigliano) is an Argentine-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University in record time. He held the Karl F. Hasselmann Endowed Chair Professorship in Engineering at Rice University and was a Professor of Bioeng...
Title:Physics At The Biomolecular Interface: Fundamentals For Molecular Targeted TherapyFormat:PaperbackProduct dimensions:483 pages, 9.25 X 6.1 X 0 inShipping dimensions:483 pages, 9.25 X 6.1 X 0 inPublished:June 20, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319809008

ISBN - 13:9783319809007

Appropriate for ages: All ages

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