PNH and the GPI-Linked Proteins

Other | April 1, 2000

byYoung, Neal S., Neal S. Young

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.
Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.
This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.
  • Outlines the chemical features of PNH
  • Explains the mechanism of hemolysis
  • Includes work on the biochemistry of glycophosphoinositol anchors
  • Contains descriptions of the chemistry and biophysics of GPI-anchored proteins

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From the Publisher

Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is...

Format:OtherDimensions:279 pages, 1 × 1 × 1 inPublished:April 1, 2000Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080492096

ISBN - 13:9780080492094

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