Poly(ethylene glycol): Chemistry and Biological Applications

Hardcover | December 1, 1997

EditorJ. Milton Harris, Samuel Zalipsky

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This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed include PEG-modified proteins, liposomes, drugs, surfaces of materials, and hydrogels. The volume also includes a review of PEG-oligonucleotides and a concise summary of the toxicology of PEG and its derivatives.

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This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed...

Format:HardcoverDimensions:500 pages, 6.18 × 9.09 × 1.61 inPublished:December 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0841235376

ISBN - 13:9780841235373

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Table of Contents

Preface 1. Samuel Zalipsky and J. Milton Harris: Introduction to Chemistry and Biological Applications of Poly(ethylene glycol) Fundamental Properties of Poly(ethylene glycol) 2. Gunnar Karlstrom and Ola Engkvist: Theory of Poly(ethylene glycol) in Solution 3. Danilo D. Lasic: The Conformation of Polymers at Interfaces 4. Peter K. Working, et al.: Safety of Poly(ethylene glycol) and Poly(ethylene glycol) Derivatives Poly(Ethylene Glycol)-Modified Liposomes and Particulates 5. Martin C. Woodle: Poly (ethylene glycol)-Grafted Liposome Therapeutics 6. Y. Okumura, et al.: Poly(ethylene oxide)-Bearing Lipids and Interaction of Functionalized Liposomes with Intact Cells 7. Sung Bum La, Yukio Nagasaki, and Kazunori Kataoka: Poly(ethylene glycol)-Based Micelles for Drug Delivery Protein Conjugates 8. P.A. Mabrouk: The Use of Poly(ethylene glycol)-Enzymes in Nonaqueous Enzymology 9. Janice L. Panza, et al.: Incorporation of Poly(ethylene glycol)-Proteins into Polymers 10. Michael S. Hershfield: Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA) 11. Merry R. Sherman, et al.: Conjugation of High-Molecular Weight Poly(ethylene glycol) to Cytokines: Granulocyte-Macrophage Colony-Stimulating Factors as Model Substrates 12. Kenneth Olson, et al.: Preparation and Characterization of Poly(ethylene glycol)ylated Human Growth Hormone Antagonist 13. Francesco M. Veronese, Paolo Caliceti, and Oddone Schiavon: New Synthetic Polymers for Enzyme and Liposome Modification 14. Irina N. Topchieva: Covalent and Noncovalent Adducts of Proteins with Water-Soluble Poly(alkylene oxides) 15. Seth P. Monkarsh, et al.: Isolation of Positional Isomers of Mono-poly(ethylene glycol)ylated Interferon/a-2a and the Determination of Their Biochemical and Biological Characteristics Conjugates of Ollgomeric and Low-Molecular Weight Substrates 16. Arthur M. Felix: Site-Specific Poly(ethylene glycol)ylation of Peptides 17. George Barany, et al.: Poly(ethylene glycol)-Containing Supports for Solid -Phase Synthesis of Peptides and Combinatorial Organic Libraries 18. Andres Jaschke: Oligonucleotide-Poly(ethylene glycol) Conjugates: Synthesis, Properties, and Applications 19. Tatsuro Ouchi, Hidetoshi Kuroda, and Yuichi Ohya: Design of Antitumor Agent-Terminated Poly(ethylene glycol) Conjugate as Macromolecular Prodrug 20. E.H. Schacht and K. Hoste: Poly(ethylene glycol)-Grafted Polymers as Drug Carriers New Functional Polymers, Surfaces, and Hydrogels 21. Samuel Zalipsky and Sunitha Menon-Rudolph: Hydrazide Derivatives of Poly(ethylene glycol) and Their Bioconjugates 22. Susan J. Sofia and Edward W. Merrill: Protein Adsorption of Poly(ethylene oxide)-Grafted Silicon Surfaces 23. Milan Mrksich and George M. Whitesides: Using Self-Assembled Monolayers That Present Oligo(ethylene glycol) Groups To Control the Interactions of Proteins with Surfaces 24. Kazunori Emoto, J. Milton Harris, and James M. Van Alstine: Electrokinetic Analysis of Poly(ethylene glycol) Coating Chemistry 25. Karin D. Caldwell: Surface Modifications with Adsorbed Poly(ethylene oxide)-Based Block Copolymers Physical Characteristics and Biological Use 26. Woonza Rhee, et al.: In vivo Stability of Poly(ethylene glycol)-Collagen Composites 27. Guohua Chen, Allan S. Hoffman, Bhagwati Kabra, and Kiran Randeri: Temperature-Induced Gelation Pluronic-g-Poly(acrylic acid) Graft Copolymers for Prolonged Drug Delivery to the Eye 28. Xuan Zhao and J. Milton Harris: Novel Degradable Poly(ethylene glycol) Esters for Drug Delivery Author Index Affiliation Index Subject Index.