Polycomb Group Proteins

Hardcover | January 5, 2017

byVincenzo Pirrotta

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Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

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Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major geno...

Dr. Pirrotta is a world leader in the area of polycomb group proteins. He attended Harvard University up to a postdoctorate level studying physical chemistry and molecular biology. He joined the new EMBL Laboratory in Heidelberg, studying gene regulation in bacteriophage lambda and then Drosophila molecular genetics. He proceeded from ...
Format:HardcoverDimensions:376 pages, 9.41 × 7.24 × 0.98 inPublished:January 5, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012809737X

ISBN - 13:9780128097373

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Table of Contents

Section 1: PRC1 Complexes

1. Variant PRC1 complexes

2. RING heterodimer formation and enzymatic activity

3. PC chromodomain

4. Histone H2A ubiquitylating PRC1 complexes

5. CBX-containing complexes and their roles

6. PRC1 and DNA damage

7. Scm and related components

8. Polycomb interaction partners

9. Drosophila PREs and cooperative recruitment

10. Binding of PRC1 complexes to PREs

11. KDM2B-containing complexes and PRC1 recruitment to CpG islands

Section 2: PRC2 Complexes

12. PRC2 structure

13. PRC2 structure and function

14. PRC2 function and feedbacks

15. PRC2 recruitment and transcription

16. Global PRC2 activities

17. Ezh2 activating mutations

18. Role of PRC2 and the memory of repression in C. elegans

19. Non-histone targets of Ezh2

20. Cytoplasmic shuttling of PRC2 and its role

Section 3: Covalent modifications of PcG proteins

21. Post-translational modifications of PRC1

22. Phosphorylation of PRC2 components

23. Ph Glycosylationand PRC1 aggregation

24. SUMOylation of Pc

25. Role of ncRNA in Polycomb repression