Polycomb Group Proteins by Vincenzo PirrottaPolycomb Group Proteins by Vincenzo Pirrotta

Polycomb Group Proteins

byVincenzo Pirrotta

Hardcover | January 5, 2017

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Polycomb Group Proteinsis a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices.

In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states.

In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions.



  • Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals
  • Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference
  • Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

About The Author

Dr. Pirrotta is a world leader in the area of polycomb group proteins. He attended Harvard University up to a postdoctorate level studying physical chemistry and molecular biology. He joined the new EMBL Laboratory in Heidelberg, studying gene regulation in bacteriophage lambda and then Drosophila molecular genetics. He proceeded from ...

Details & Specs

Title:Polycomb Group ProteinsFormat:HardcoverDimensions:372 pages, 9.41 × 7.24 × 0.98 inPublished:January 5, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012809737X

ISBN - 13:9780128097373

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Table of Contents

Chapter 1. Introduction to Polycomb Group Mechanisms

Chapter 2. The Role of RAWUL and SAM in Polycomb Repression Complex 1 Assembly and Function

Chapter 3. The Chromodomain of Polycomb: Methylation Reader and Beyond

Chapter 4. Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes

Chapter 5. Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module

Chapter 6. Cooperative Recruitment of Polycomb Complexes by Polycomb Response Elements

Chapter 7. Polycomb Function and Nuclear Organization

Chapter 8. Molecular Architecture of the Polycomb Repressive Complex 2

Chapter 9. Polycomb Repressive Complex 2 Structure and Function

Chapter 10. Regulation of PRC2 Activity

Chapter 11. Activating Mutations of the EZH2 Histone Methyltransferase in Cancer

Chapter 12. PcG Proteins in Caenorhabditis elegans

Chapter 13. Global Functions of PRC2 Complexes