Practical Biostatistics: A Friendly Step-by-step Approach For Evidence-based Medicine

Paperback | July 26, 2012

byMendel Suchmacher, Mauro GellerEditorMendel Suchmacher

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Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials. Customized presentation for biological investigators with examples taken from current clinical trials in multiple disciplines Clear and concise definitions and examples provide a pragmatic guide to bring clarity to the applications of statistics in improving human health Addresses the challenge of assimilation of mathematical concepts to better interpret literature, to build stronger studies, to present research effectively, and to improve communication with supporting biostatisticians

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From the Publisher

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical rese...

From the Jacket

It is no secret that biostatistics has become a necessary, but dreaded, tool in today's research and clinical settings. With obvious benefits in terms of efficacy and practical results, assimilation of the underpinning mathematical and statistical requirements can nevertheless challenge even the most devoted clinical investigator or me...

* Board Certification in Internal Medicine and Hematology-Hemotherapy* Post-graduation in Pharmaceutical Medicine (Universidade Federal do Estado de Sao Paulo)* Clinical Research Dpt. (Gross Pharmaceuticals)* Member of the American College of Physicians* Professor of Clinical Immunology - Carlos Chagas Institute of Medical Post-graduat...
Format:PaperbackDimensions:248 pages, 9 × 6 × 0.68 inPublished:July 26, 2012Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0124157947

ISBN - 13:9780124157941

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Table of Contents

PART 1 - STUDY TYPE DETERMINATION 1. Epidemiological studies 2. Analytical studies 3. Summary

PART 2 - OBSERVATIONAL STUDIES 4. Determination of association strength between an exposure factor and an event in observational studies 5. Increasing accuracy in observational studies

PART 3 - STEP-BY-STEP BIOSTATISTICS OF A CLINICAL TRIAL 6. STEP 1: Investigator's hypothesis and expression of its corresponding outcome 7. STEP 2: n estimation and n assessment of a published trial 8. STEP 3: Organization of variables and endpoints 9. STEP 4: Measures for results expression of a clinical trial 10. STEP 5: Determination of normality or non-normality of data distribution 11. STEP 6: Hypothesis testing 12. STEP 7: Correlating sample data with the general population - 95% confidence Interval

PART 4 - ADDITIONAL CONCEPTS IN BIOSTATISTICS 13. Individual and collective benefit and risk indexes inferable from intervention cohort studies 14. Statistical assessment of diagnostic tests for the clinic 15. Systematic reviews and meta-analyses 16. Correlation and regression 17. Per protocol analysis and intention to treat analysis

Editorial Reviews

"...strongly recommended as a practical guide for readers interested in applied biostatistics. Each chapter of the book is accompanied by practical examples and a huge set of reflection questions and answers."--Zentralblatt MATH, Practical Biostatistics "With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials."--Doody.com, April 24, 2013 "Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." Mauri Carakushansky, MD Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida "This work by Dr. Suchmacher and Dr. Geller is bound to become a classic and should be readily available on the desk, shelf and on line." Salin Dahlben, Harvard University, Clinical Assistant Professor in Psychiatry, Tufts University "Dr. Suchmacher and Dr. Geller are experienced researchers and writers in the clinical research field, who were able to fathom the often confusing realm of Statistics applied to biological sciences, and to come back with a pragmatic study proposal for interested medical students and healthcare professionals [.] In my opinion, 'Practical Biostatistics' will undoubtedly be welcomed as one of the books designed to bring medical students and healthcare professionals alike, closer to a better understanding of this inescapable issue." Spyros G.E. Mezitis, Assistant Professor of Clinical Medicine, The New York Presbyterian Hospital Weill, Cornell Medical Center "I believe the result of [Drs. Suchmacher and Geller's] efforts will prove useful for many medical students and researchers, who must thrive in an era when Biostatistics is destined to be an ever present matter." Allan E. Rubenstein, Clinical Professor of Neurology, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, Langone Medical Center, School of Medicine, New York University Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida