Practical Process Research and Development

Other | June 1, 2000

byAnderson, Neal G., Neal G. Anderson

not yet rated|write a review
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

  • Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
  • Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
  • Includes over 100 tips for rapid process development
  • Presents guidelines for implementing and troubleshooting processes

Pricing and Purchase Info

$161.69 online
$209.97 list price (save 22%)
In stock online
Ships free on orders over $25

From the Publisher

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being h...

Neal G. Anderson, Ph.D., has worked for over 20 years in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan and completed post-doctoral studies at McNeil Laboratories. With almost 18 years in process R&D at Brist...

other books by Anderson, Neal G.

Field-Coupled Nanocomputing: Paradigms, Progress, and Perspectives
Field-Coupled Nanocomputing: Paradigms, Progress, and P...

Kobo ebook|May 31 2014

$64.19 online$83.37list price(save 23%)
Practical Process Research and Development
Practical Process Research and Development

Hardcover|Mar 20 2000

$189.03 online$234.95list price(save 19%)
Format:OtherDimensions:354 pages, 1 × 1 × 1 inPublished:June 1, 2000Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080514480

ISBN - 13:9780080514482

Customer Reviews of Practical Process Research and Development

Reviews

Extra Content

Table of Contents

Foreword by K. Barry Sharpless. Foreword by Jerome L. Moniot. Preface. About the Author. Approaches to Process Development. Route Selection. Reagent Selection. Solvent Selection. Running the Reaction. Effects of Water. In-Process Controls. Optimizing the Reaction by Minimizing Impurities. Optimizing Catalytic Reactions. Work-Up. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying. Final Product Form and Impurity Considerations. Vessels and Mixing. Preparing for and Implementing the Scale-up Run. Troubleshooting. Chiral Syntheses. General Index. Reaction Type Index. Reagent Index.