Practical Process Research and Development

Hardcover | March 20, 2000

byNeal G. AndersonEditorNeal G. Anderson

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R primarily organic chemists, and academicians particularly those involved in a growing number of start-up companies and students who need insight into industrial process R optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

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From the Publisher

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R primarily organic chemists, and academicians particularly those involved in a growing number of start-up companies and students who need insight into...

From the Jacket

Bringing a compound to market quickly and profitably requires efficient andcost-effective processes for preparing large amounts of the target compoundand intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarelytaught in academia and may take...

Neal G. Anderson, Ph.D., has worked for over 20 years in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan and completed post-doctoral studies at McNeil Laboratories. With almost 18 years in process R&D at Brist...

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Format:HardcoverDimensions:354 pagesPublished:March 20, 2000Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0120594757

ISBN - 13:9780120594757

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Table of Contents

Foreword by K. Barry Sharpless. Foreword by Jerome L. Moniot. Preface. About the Author. Approaches to Process Development. Route Selection. Reagent Selection. Solvent Selection. Running the Reaction. Effects of Water. In-Process Controls. Optimizing the Reaction by Minimizing Impurities. Optimizing Catalytic Reactions. Work-Up. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying. Final Product Form and Impurity Considerations. Vessels and Mixing. Preparing for and Implementing the Scale-up Run. Troubleshooting. Chiral Syntheses. General Index. Reaction Type Index. Reagent Index.

Editorial Reviews

"Neal Anderson has assembled an immense amount of practical information that is absolutely essential to the design and execution of safe, reliable, efficient large-scale syntheses. Critical facts once hidden in obscure sources or chemical folklore are now organized for ready access. Countless illustrative reactions and sequences from the latest literature are discussed lucidly, and impress upon the reader the scope and sophistication of modern organic process chemistry. This book is a must for beginners and old hands alike."- Raymond Conrow, Assistant Technical Director, Chemical Preparations Research, Alcon Laboratories"Perhaps the highest praise one can give this book is to say that the Foreword by Barry Sharpless raises very high expectations...and the book meets and at times exceeds those expectations."- Organic Process Research & Development