Prenatal Diagnosis by Sinuhe HahnPrenatal Diagnosis by Sinuhe Hahn

Prenatal Diagnosis

EditorSinuhe Hahn

Paperback | November 19, 2010

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In this thorough and state-of-the-art book, top experts provide cutting edge techniques which greatly expand the depth and scope of classical invasive prenatal diagnosis. The book features a totally unique focus on novel non-invasive approaches for prenatal diagnosis. Following the Methods in Molecular BiologyT series format, the chapters feature step-by-step laboratory protocols, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls.
Title:Prenatal DiagnosisFormat:PaperbackDimensions:345 pages, 9.25 × 6.1 × 0.68 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617377872

ISBN - 13:9781617377877

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Table of Contents

List of ContentsMethods in Molecular Biology: Prenatal Diagnosis: PrefaceSinuhe Hahn  Part I: Invasive approaches:1. Spectral Karyotyping (SKY): Applications in prenatal diagnosticsSusanne Mergenthaler-Gatfield, Wolfgang Holzgreve and Sinuhe Hahn2. Characterization of prenatally assessed de novo small supernumerary marker chromosomes (sSMC) by molecular cytogeneticsThomas Liehr3. Rapid prenatal aneuploidy screening by fluorescence in situ hybridization (FISH)Anja Weise and Thomas Liehr4. Application of multi-PRINS to simultaneously identify chromosomes 18, X and Y in prenatal diagnosisMacoura Gadji, Kada Krabchi, Ju Yan, and Régen Drouin5. Prenatal diagnosis using array CGHCatherine D. Kashork, Aaron Theisen and Lisa G. Shaffer6. Prenatal detection of chromosome aneuploidy by quantitative-fluorescence PCRKathy Mann, Erwin Petek and Barbara Pertl7. Real-time quantitative PCR for the detection of fetal aneuploidiesBernhard Zimmermann and Lech Dudarewicz8. MLPA for prenatal diagnosis of common occurring aneuploidiesJan Schouten and Robert-Jan Galjaard9. MALDI-TOF mass spectrometry for trisomy detectionDorothy Huang, Matthew R. Nelson and Wolfgang Holzgreve10. Rapid detection of fetal mendelian disorders: Thalassemia and sickle cell syndromesJoanne Traeger-Synodinos, Christina Vrettou and Emmanuel Kanavakis11. Rapid detection of of fetal mendelian disorders: Tay-Sachs diseaseEsther Guetta and Leah Peleg12. Arrayed primer extension reaction for genotyping on oligonucleotide microarrayJanne Pullat and Andres Metspalu13. A fast microelectronic array for screening and prenatal diagnosis of beta-thalasemia Barbara Foglieni, Silvia Galbiati, Maurizio Ferrari, and Laura Cremonesi Part 2: Noninvasive approaches14. RHD genotyping from maternal plasma: Guidelines and technical challengesNeil D. Avent15. Isolation of cell-free DNA from maternal plasma using manual and automated systemsDorothy J. Huang, Susanne Mergenthaler-Gatfield, Sinuhe Hahn, Wolfgang Holzgreve and Xiao Yan Zhong16. Fetal DNA - strategies for optimal recoveryTobias J. Legler, Klaus-Hinrich Heermann, Zhuir Liu, Aicha Ait Soussan, and Ellen C. van der Schoot17. Quantification of circulatory fetal DNA in the plasma of pregnant womenBernhard G. Zimmermann, Deborah G Maddocks, and Neil Avent18. Detection and quantification of fetal DNA in maternal plasma using LightCycler TechnologyYuditiya Purwosunu, Akihiko Sekizawa, and Takashi Okai19. Size fractionation of cell-free DNA in maternal plasma and its application innon-invasive detection of fetal single gene point mutationsYing Li, Wolfgang Holzgreve and Sinuhe Hahn20. MALDI-TOF mass spectrometry for analyzing cell-free fetal DNA in maternal plasmaChunming Ding21. Isolation of cell-free RNA from maternal plasmaXiao Yan Zhong, Wolfgang Holzgreve, and Dorothy J. Huang 22. A microarray approach for systematic identification of placental-derived RNA markers in maternal plasmaNancy B. Y. Tsui and Y. M. Dennis Lo23. A novel method to identify syncytiotrophoblast-derived RNA products representative of trisomy 21 placental RNA in maternal plasma Attie T. J. J. Go, Allerdien Visser, Marie van Dijk, Monique A. M. Mulders, Paul Eijk, Bauke Ylstra, Marinus A. Blankenstein, John M. G. van Vugt, and Cees B. M. Oudejans 24. Method for the extraction of high quantity and quality cell-free DNA from amniotic fluid Olav Lapaire, Kirby L. Johnson, and Diana W. Bianchi25. Detection of new screening markers for fetal aneuploidies in maternal plasma: A proteomic approachChinnapapagari Satheesh Kumar Reddy, Wolfgang Holzgreve and Sinuhe Hahn

Editorial Reviews

From the reviews:"This comprehensive book describes invasive and noninvasive techniques for diagnosing various chromosomal and genetic disorders prenatally. . the book was written for molecular biologists and those involved in research in the area of prenatal medicine. . has a consistent style to convey the information, making each chapter readable and relatable to the previous chapters. . as a compilation of techniques and a description of the situations in prenatal medicine in which each technique might be useful, this is an excellent and detailed resource." (Gilad A. Gross, Doody's Review Service, August, 2008)