Presenilins and Alzheimer's Disease by Steven G. YounkinPresenilins and Alzheimer's Disease by Steven G. Younkin

Presenilins and Alzheimer's Disease

bySteven G. YounkinEditorRudolph E. Tanzi

Paperback | February 29, 2012

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The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Title:Presenilins and Alzheimer's DiseaseFormat:PaperbackDimensions:100 pagesPublished:February 29, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642721052

ISBN - 13:9783642721052

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Table of Contents

Molecular Genetics of the Presenilins in Alzheimer's Disease.- Alzheimer's Disease: A Matter of Dominance.- Alternative Endoproteolysis of the Presenilins and Familial Alzheimer's Disease.- The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer's Disease Increase the Extracellular Concentration of A?1-42(43).- Metabolism and Function of Presenilin 1.- Mechanistic Studies of the Effect of Presenilins 1 and 2 on APP Metabolism.- Presenilin 2 - APP Interactions.- The Cellular Biology of Presenilin Proteins and a Novel Mechanism of Amyloid ?-Peptide Generation.- Regulation of Presenilin 1 Phosphorylation and Transcriptional Activation of Signal Transduction-Induced Genes by Muscarinic Receptors.- Neuronal Regulation of Presenilin-1 Processing.- Transgenic Approaches to the Study of Alzheimer's Disease.