Primer on Multiple Sclerosis was developed to provide a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS. The readeris provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of the newest directions in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspectsof MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain.Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewingthe scientific literature in these areas.