Principles of Bone Biology, Two-Volume Set

Other | January 1, 2002

byBilezikian, John P., John P. Bilezikian

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Principles of Bone Biologyis the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.

The most current and timely source of information about the biology and pathology of bone
Provides succinct coverage of the subject
Contributors include over 200 of the most respected researchers in the field
Extensive table of contents and index for easy reference
Easy-to-read and highly informative to both the newcomer and the initiated to the field
Spans the spectrum from molecular biology to in vivo pharmacology
Complete bibliography with each entry fully referenced for additional background reading
First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996

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From the Publisher

Principles of Bone Biologyis the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientif...

Dr. Rodan graduated from the Hebrew University Medical School (Jerusalem) in 1965, had two years residency in oncology and obtained a Ph.D. in chemistry in 1970 from the Weizmann Institute of Science, Israel. In 1970, he joined the University of Connecticut, where he became chairman of the Department of Oral Biology in 1978. In 1985, h...

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Format:OtherDimensions:1696 pages, 1 × 1 × 1 inPublished:January 1, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080539602

ISBN - 13:9780080539607

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Extra Content

Table of Contents


Cell Biology
The Structure & Development of the Skeleton
Biomechanics of Bone
Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Mesenchymal Stem Cells & Osteoblast Lineage
Transcriptional Control of Osteoblast Differentiation and Function
The Osteocyte
Cells of Bone: Osteoclast Generation
Osteoclast Function
Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts
Apoptosis in Bone Cells
Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells

Type I Collagen: Structure, Synthesis, and Regulation
Collagen Crosslinking & Metabolism
Bone Matrix Proteoglycans & Glycoproteins
Bone Proteinases
Cell Surface Attachment Molecules
Intercellular Junctions and Cell-Cell Communication in Bone

Bone Remodeling and Mineral Homeostasis
Histomorphometric Analysis of Bone Remodeling
Phosphorus Homeostasis & Related Disorders
Magnesium Homeostasis
Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium
The Biology of the Extracellular Ca2+-Sensing Receptor (CaR)

The Hormones of Bone
Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide
Parathyroid Hormone - Molecular Biology
Parathyroid Hormone-Receptor Interactions
Actions of Parathyroid Hormone
Renal and Skeletal Actions of PTH and PTHrP
Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues
Vascular, Cardiovascular and Neurological Actions of PTHrP
Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses
Vitamin D Gene Regulation
Photobiology and Non-Calcemic Actions of Vitamin D
The Structure and Molecular Biology of the Calcitonin Receptor
Physiology & Pathophysiology of Calcitonin
Amylin & CGRP

Other Systemic Hormones That Influence Bone Metabolism
Estrogens & Progestins
Selective Estrogen Receptor Modulators (SERMs)
Mechanisms of Estrogen Action in Bone
Thyroid Hormone & Bone
Clinical and Basic Aspects of Glucocorticoid Action in Bone
Effects of Diabetes & Insulin on Bone Physiology
Androgens: Receptor Expression and Steroid Action in Bone
Kinins & Neuro-Osteogenic Factors

Local Regulators
The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology
Platelet-Derived Growth Factor & the Skeleton
Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
Vascular Endothelial Growth Factors
Transforming Growth Factor (beta)
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors & Actions
Colony-Stimulating Factors
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Prostaglandins & Bone Metabolism
Nitric Oxide and other Vasoactive Agents


Molecular Basis of PTH Overexpression
Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
Multiple Endocrine Neoplasia Type I
The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2
Systemic Factors in Skeletal Manifestations of Malignancy
Local Factors in Skeletal Malignancy
Molecular Basis of PTH Underexpression
Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
Signal Transduction via G Proteins; Pseudohypoparathyroidism
Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright Syndrome
Osteogenesis Imperfecta
Hereditary Deficiencies in Vitamin D Action.
Oncogenic Osteomalacia
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man
Paget's Disease of Bone
Genetic Determinants of Bone Mass
Pathophysiology of Osteoporosis
Evaluation of Risk for Osteoporosis Fractures


Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone
Calcium Receptors as Novel Drug Targets
Bisphosphonates: Mechanisms of Action
Fluoride in Osteoporosis
The Pharmacology of Estrogens in Osteoporosis
Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs
Molecular and Clinical Pharmacology of Calcitonin
Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases
Anabolic Steroid Effects on Bone in Women
Estrogen Effects on Bone in the Male Skeleton
Mechanisms of Exercise Effects on Bone


Application of Transgenic Mice to Problems of Skeletal Bone
Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes
Current Methodologic Issues in Cell & Tissue Culture
Biochemical Markers of Bone Metabolism
Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry
Controversies in Bone Mass Measurement
Macro and Micro Imaging of Bone Architecture
Transilial Bone Biopsy
Animal Models in Osteoporosis Research
Defining the Genetics of Osteoporosis - Using the Mouse to Understand Man